中国输血杂志2025，Vol.38Issue(10)：1355-1360,6.DOI:10.13303/j.cjbt.issn.1004-549x.2025.10.009
河北地区献血者人群HCV感染趋势及分布特征分析
Analysis of the trend and distribution characteristics of hepatitis C virus infection among blood donors in Hebei Province
摘要
Abstract
Objective To analyze the changing trend and distribution characteristics of hepatitis C virus(HCV)infec-tion among blood donors in Hebei,thereby providing data to support strategy and procedure adjustment for blood collection and supply institutions.Methods Data from 12 blood stations in Hebei Province from 2012 to 2021 were collected.These data were analyzed to determine trends in anti-HCV antibody double reagent reactive rate and to characterize its distribution among different donor categories,genders and birth cohorts.Results During the period from 2012 to 2021,a total of 7.4576 million samples were tested at 12 blood stations in Hebei Province,with 3.4659 million(46.47%)from first-time donors,and 3.9917 million(53.53%)from repeat donors.The number(of anti-HCV double reagent reactive samples was 7167(9.61/10 000).The anti-HCV double reagent reactive rate showed a annual downward trend(P<0.05),from 17.40/10 000 at the beginning to 4.95/10 000 at the end of the study period.Additionally,the double reagent reactive rate of repeat blood donors had remained below 1/10 000 since 2017.The double reagent reactive rate of first-time blood donors(19.42/10 000)was higher than in repeat donors(1.09/10 000)(P<0.05),and the double-reagent reactive rate of fe-male first-time blood donors(20.98/10 000)was higher than that of male first-time blood donors(18.49/10 000)(P<0.05).The anti-HCV double reagent reactive rate among first-time donors exhibited two distinct peaks within the pre-1976 and 1989-1994 birth cohorts,with notable gender differences observed in both peak periods.The rate of double reagent re-active in females born before 1976(52.22/10 000)was higher than that in males(32.28/10 000)(P<0.05),while that of males born in 1989-1994 was higher(25.75/10 000)than that of females(14.28/10 000)(P<0.05).Conclusion The prevalenc of HCV infection among blood donors in Hebei Province has shown a consistent year-over-year decline over the study period.The majority of infected individuals are found among the first-time blood donors born before 1995.These trends and characteristics provide valuable insights for developing pre-blood collection screening strategies,analyzing nucleic acid test data in blood screening,adjusting blood screening procedures,and provide evidence for targeted screening of high-risk populations as part of public health initiatives to eliminate hepatitis C.关键词
HCV/感染/初次/重复献血者/采血前初筛Key words
HCV/infection/first-time/repeat blood donors/pre-blood collection screening分类
临床医学引用本文复制引用
韩卫,张慧贤,王艳彬,赵雅姿,韩雪峰,唐昆,康洁..河北地区献血者人群HCV感染趋势及分布特征分析[J].中国输血杂志,2025,38(10):1355-1360,6.基金项目
河北省卫生健康委员会指令性课题(20180934) （20180934）
