中国输血杂志2025，Vol.38Issue(10)：1370-1376,7.DOI:10.13303/j.cjbt.issn.1004-549x.2025.10.011
电子交叉配血与红细胞意外抗体检出率的相关性分析研究
Correlation between electronic cross-matching and the detection rate of unexpected antibodies in red blood cells
摘要
Abstract
Objective To analyze changes in Rh system antibodies among antibody-positive patients and evaluate the efficacy of Rh phenotype-matched electronic cross-matching(hereinafter referred to as Rh-ECM).Methods A retrospec-tive analysis was performed on antibody screening data of 48 254 patients in our hospital from December 2023 to March 2025.The antibody screening results were compared between the pre-application phase(n=46 346,control group)and post-application phase(n=48 254,experimental group)of Rh-ECM technology,focusing on the changes in the proportion of Rh system antibodies,with statistical analysis conducted using SPSS 26.0 software.Meanwhile,the initial and re-exami-nation situations of Rh antibody in the antibody screening of approximately 20 000 person-times each before(June 2019 to June 2020,n=21 048)and after(July 2020 to April 2021,n=20 965)of Rh-ECM were evaluated to explore the influence of Rh-ECM on the detection rate of Rh antibody.Results After Rh-ECM implementation,345 positive cases(0.7%)(345/48 254)were detected among 48 254 patients,primarily consisting of mns system antibodies(128 cases,37.1%)(128/345)and rh system antibodies(95 cases,27.5%)(95/345).Before Rh-ECM implementation,199 positive cases(0.4%)(199/46 346)were detected among 46 346 patients,with rh system antibodies accounting for 97 cases(48.7%)(97/199).The difference in the composition ratio of Rh antibodies between the two phases was statistically significant(P<0.001),and the relative risk ratio of Rh antibody detection after Rh-ECM implementation was 56.5%compared to before.Another set of data analysis showed that before Rh-ECM,there were 37 cases with initial positive results and 8 cases with re-examination positive results;after Rh-ECM,these numbers were 44 and 2 respectively There was a statistically significant difference in the re-examination positive rate of Rh antibodies between the two stages(P<0.05).Conclusion The imple-mentation of Rh-ECM technology significantly reduced the proportion of Rh system antibodies among patients with positive antibody screening results.This suggests that Rh-ECM can effectively reduce the detection rate of Rh antibodies,which may be related to the reduced risk of antibody production due to Rh-matched transfusion,thus improving transfusion safety.Therefore,Rh-ECM is worthy of broader promotion in clinical transfusion testing.关键词
电子交叉配血/Rh系统抗体/抗体筛查/临床输血/统计分析Key words
electronic cross-matching/Rh antibody/antibody screening/clinical blood transfusion/statistical analysis分类
临床医学引用本文复制引用
娄璨,雷航,王钰箐,龚淞颂,王学锋,邹纬,蔡晓红,陈诗恺..电子交叉配血与红细胞意外抗体检出率的相关性分析研究[J].中国输血杂志,2025,38(10):1370-1376,7.基金项目
国家自然科学基金委员会面上项目(82070194) （82070194）
上海"医苑新星"杰出青年医学人才项目(20254Z0009) （20254Z0009）
