中国输血杂志2025，Vol.38Issue(10)：1408-1412,5.DOI:10.13303/j.cjbt.issn.1004-549x.2025.10.017
一例血浆置换联合利妥昔单抗治疗肝移植术后过客淋巴细胞综合征报告
Plasma exchange combined with rituximab for the treatment of passenger lymphocyte syndrome after liver trans-plantation
摘要
Abstract
Objective To investigate the efficacy of therapeutic plasma exchange and rituximab in the treatment of pas-senger lymphocyte syndrome(PLS)after ABO incompatible liver transplantation.Methods PLS diagnosis was performed on the transplant patient using immunohematology testing techniques such as direct anti human globulin test(DAT),red blood cell elution test,and blood type antibody titer detection,combined with changes in hemolysis laboratory indicators;Severe immune hemolysis caused by PLS treated with red blood cell transfusion,therapeutic plasma exchange,and ritux-imab.Results The patient was diagnosed with PLS 9 days after transplantation,and hemolysis caused by PLS continued until 20 days after transplantation;After three rounds of therapeutic plasma exchange and treatment with 100 mg rituximab,the titer of the patient's immune blood type antibody(IgG anti-B)decreased from 128 to 8 and was maintained until 27 days after transplantation.The patient's hemolytic symptoms improved and were discharged 32 days after transplantation.Con-clusion This case explores the application of therapeutic plasma exchange and rituximab in the treatment of severe hemoly-sis in PLS after transplantation,providing a reference for establishing standardized management of PLS after solid organ transplantation.关键词
过客淋巴细胞综合征/肝移植/血浆置换/利妥昔单抗Key words
passenger lymphocyte syndrome/liver transplantation/plasma exchange/rituximab分类
临床医学引用本文复制引用
吴承高,邹娟,胡飘萍,刘威,况林菊,吴义泽,乐爱平..一例血浆置换联合利妥昔单抗治疗肝移植术后过客淋巴细胞综合征报告[J].中国输血杂志,2025,38(10):1408-1412,5.基金项目
江西省自然科学基金项目(20232BAB216040),江西省教育厅重点项目(GJJ210112),输血医学江西省重点实验室(20212BCD42006) （20232BAB216040）
