中国实用妇科与产科杂志2025，Vol.41Issue(10)：1027-1030,4.DOI:10.19538/j.fk2025100114
子宫切除术后患者阴道残端人乳头瘤病毒基因型分析及其对阴道残端上皮细胞的影响
Genotype analysis of human papillomavirus in vaginal stump of patients after hysterectomy and its impact on vaginal vault epithelial cells
摘要
Abstract
Objective To investigate the distribution of human papilloma virus(HPV)genotypes and analyze the impact of HPV infection on vaginal vault epithelial cell lesions.Methods A total of 191 patients with positive HPV genotyping results from exfoliated vaginal stump cells after hysterectomy at Yancheng Maternal and Child Health Care Hospital Affiliated to Yangzhou University(January 2021-December 2024)were retrospectively analyzed.The HPV genotype distribution and its correlation with vaginal cell lesions were statistically analyzed.Results Twenty-three HPV subtypes were detected in the 191 patients.The top six high-risk HPV genotypes were 52,16,58,31,51,and 18 subtypes.Single-type,dual-type,and multiple-type infections accounted for 102(53.40％),54(28.27％),and 26(13.61％)cases,respectively,with one patient infected by six subtypes.Colposcopy results revealed that there was no intraepithelial lesion or malignancy(NILM)in 73 cases(38.22％),while there was vaginal intraepithelial neoplasia(VaIN)grade Ⅰ in 95 cases(49.74％),grade Ⅱ n 20(10.47％),and grade Ⅲ in 3(1.57％).The number of HPV subtypes showed no statistically significant correlation with hysterectomy indications or vaginal vault epithelial pathology degree.However,HPV 16 infection in vaginal stump was significantly associated with the degree of vaginal vault epithelial pathology.Conclusions The genotypes of HPV infection in vaginal stump are distributed differently in different regions.It is recommended that women in Yancheng area should give priority to HPV 9 vaccine,and HPV-infected patients should be properly treated,especially HPV 16-positive patients,who should receive timely TCT and colposcopy in a standardized manner for early diagnosis and treatment of VaIN.关键词
人乳头瘤病毒基因型/阴道上皮内瘤变/人乳头瘤病毒疫苗/阴道残端/阴道镜检查Key words
HPV genotypes/vaginal intraepithelial neoplasia(VaIN)/HPV vaccine/vaginal stump/colposcopy分类
临床医学引用本文复制引用
张丽丽,唐雪丽,耿莉,袁丽娟,项达军..子宫切除术后患者阴道残端人乳头瘤病毒基因型分析及其对阴道残端上皮细胞的影响[J].中国实用妇科与产科杂志,2025,41(10):1027-1030,4.基金项目
盐城市卫健委医学科研项目(YK2021048,YK2021049) Medical Research Project of Yancheng Health Commission(YK2021048,YK2021049) （YK2021048,YK2021049）
