中国实用妇科与产科杂志2025，Vol.41Issue(10)：1031-1033,1038,4.DOI:10.19538/j.fk2025100115
组蛋白甲基转移酶SMYD3在子宫内膜癌中的表达及意义
Expression of histone methyltransferase SMYD3 in endometrial carcinoma and its significance
摘要
Abstract
Objective To investigate the expression and significance of histone methyltransferase SMYD3 in endometrial carcinoma.Methods Totally 85 patients with endometrial cancer who underwent surgical treatment at The Tenth Affiliated Hospital,Southern Medical University from January 2014 to December 2020 were selected.The expression of SMYD3 in endometrial carcinoma tissue,atypical endometrial hyperplasia tissue,and normal endometrium tissue was assessed by immunohistochemical staining.The correlation between SMYD3 expression and clinicopathological characteristics and prognosis of patients was analyzed.Results The positive rate of SMYD3 expression in the endometrial carcinoma tissue was 83.53％,which was higher than that in atypical endometrial hyperplasia tissue(43.33％)and normal endometrium tissue(26.67％),and the difference was statistically significant(P＜0.05).The expression level of SMYD3 was associated with FIGO stage,lymphovascular space involvement,and lymph node metastasis in patients with endometrial carcinoma(P＜0.05).The patients with higher SMYD3 expression had shorter overall survival time than those with lower SMYD3 expression(P＜0.05).Conclusion The expression of SMYD3 is high in endometrial carcinoma,which is closely correlated with tumour progression and poor prognosis,suggesting that it can be used as a potential prognostic indicator and therapeutic target.关键词
组蛋白甲基转移酶/SMYD3/子宫内膜癌Key words
histone methyltransferase/SMYD3/endometrial carcinoma分类
临床医学引用本文复制引用
叶伟标,李广柳,朱莹,禤文婷,李仲均..组蛋白甲基转移酶SMYD3在子宫内膜癌中的表达及意义[J].中国实用妇科与产科杂志,2025,41(10):1031-1033,1038,4.基金项目
National Natural Science Foundation of China(82103269) （82103269）
Guangdong Basic and Applied Basic Research Foundation(2022A1515140168) （2022A1515140168）
Guangdong Provincial Medical Research Fund(C2023114) （C2023114）
Open Project from the Dongguan Songshan Lake Large Scientific Facility(KFKT2022B01) 国家自然科学基金(82103269),广东省基础与应用基础研究基金(2022A1515140168) （KFKT2022B01）
广东省医学科研基金(C2023114) （C2023114）
东莞松山湖大科学装置散裂中子源开放课题(KFKT2022B01) （KFKT2022B01）
