中国兽医科学2025，Vol.55Issue(10)：1319-1327,9.DOI:10.16656/j.issn.1673-4696.2025.0167
水佐剂增强磷酸钙矿化口蹄疫病毒样颗粒疫苗的黏膜免疫效果
Water-based adjuvants enhance the mucosal immune response of calcium phosphate-mineralized foot-and-mouth disease virus-like particles vaccine
摘要
Abstract
To boost the mucosal immune response of calcium phosphate mineralized foot-and-mouth disease(FMD)virus-like particles(VLPs-CaP),two water-based adjuvants(IMS1313 and J1)were com-bined with VLPs-CaP and administered intranasally to mice.HE staining revealed no major organ damage in any vaccine group,indicating good biocompatibility.ELISA detected IgA in mucosal tissues and IgG and cytokines in serum.Both adjuvants enhanced the mucosal immune response,with VLPs-CaP-J1 showing significantly higher IgA levels at 17 days post-immunization(P＜0.01)and higher IgG,IL-2,IL-4,and IFN-γ levels at 24 days post-immunization(P＜0.01)compared with VLPs-CaP alone.This study offers a new FMD vaccine with effective mucosal immunity.关键词
磷酸钙矿化/口蹄疫病毒样颗粒/水佐剂/黏膜免疫Key words
calcium phosphate mineralization/foot-and-mouth disease virus-like particles/water-basedadjuvants/mucosal immunity分类
农业科技引用本文复制引用
谢茜茜,王翱飞,张珍珍,孙世琪,郭慧琛,郭春和,滕志东,谢永生..水佐剂增强磷酸钙矿化口蹄疫病毒样颗粒疫苗的黏膜免疫效果[J].中国兽医科学,2025,55(10):1319-1327,9.基金项目
甘肃省科技重大专项(24ZDWA004) （24ZDWA004）
江西省教育厅科学技术研究项目(GJJ2401617) （GJJ2401617）
宁夏重点研发计划项目(2024BBF02017) （2024BBF02017）
博士后科学基金项目(2023M733819) （2023M733819）
