中国兽医科学2025，Vol.55Issue(10)：1399-1406,8.DOI:10.16656/j.issn.1673-4696.2025.0171
五倍子颗粒对靶动物蛋鸡的安全性评价
Safety assessment of Galla chinensis granules in target animal laying hens
摘要
Abstract
To evaluate the safety of Galla chinensis granules in laying hens(target animals),3 groups Hailanbrown laying hens were fed by 1,3,or 5 times clinically recommended dose of Galla chinensis granu-les,and a blank control group was set up.The changes in production performance were recorded,egg quality,blood physiological and biochemical indexes were determined,organ indexes and intestinal permeability were measured,and histological changes were observed.The results showed that no abnormal changes oc-curred in the clinical conditions.Compared with the blank control group,there were no significant dif-ferences in weight,production performance,egg quality,blood physiological and biochemical indexes,and organ index,and no lesions were found in autopsy and tissue microstructure.Intestinal permeability tests revealed that the expressions of the CLDN1 in the jejunal epithelium and the OCLN in the ileal epi-thelium were significantly upregulated in the high dose group(P＜0.05).Similarly,the medium dose group exhibite significant upregulation of CLDN1 and OCLN in the ileal epithelium(P＜0.05).The results indicate that Galla chinensis granules are safe in the dose below 0.5 g/kg and can enhance the intestinal barrier.关键词
五倍子颗粒/蛋鸡/安全性评价/单宁酸Key words
Galla chinensis granules/laying hens/safety assessment/tannic acid分类
畜牧业引用本文复制引用
李穗湘,茹梦珂,郝宝成,杨珍,刘宇,王玲,王胜义,胡庭俊,崔东安..五倍子颗粒对靶动物蛋鸡的安全性评价[J].中国兽医科学,2025,55(10):1399-1406,8.基金项目
国家重点研发计划专项(2022YFD1801102) （2022YFD1801102）
国家重点研发计划项目(2023YFD1800802) （2023YFD1800802）
中央级公益性科研院所基本科研业务费专项(Y2022YJ14) （Y2022YJ14）
兽用天然药物与抗生素替代创新工程项目(25-LZIHPS-03) （25-LZIHPS-03）
