中国现代医学杂志2025，Vol.35Issue(21)：48-52,5.DOI:10.3969/j.issn.1005-8982.2025.21.008
盐酸阿芬太尼在小儿疝气腹腔镜手术全凭静脉麻醉诱导中的作用
Role of afentanil hydrochloride in induction of intravenous anesthesia in laparoscopic hernia surgery in children
摘要
Abstract
Objective To analyze the effect of afentanil hydrochloride on induction of intravenous anesthesia in laparoscopic surgery for children with hernia.Methods The clinical data of 79 children with laparoscopic hernia surgery admitted to Anhui Children's Hospital during September 2024 to February 2025 were retrospectively analyzed.They were divided into 2 groups according to different induction methods of intravenous anesthesia.40 cases in the control group were induced by sufentanil,and 39 cases in the observation group were induced by afentanil hydrochloride.The mean arterial pressure(MAP)and heart rate(HR)of the two groups were recorded before anesthesia induction(T0),during laryngeal mask placement(T1)and laryngeal mask removal(T2).The pain in the recovery period(FLACC scale),anesthesia recovery indexes and safety were analyzed in the two groups.Results The comparison of MAP and HR at T0,T1,and T2 between the observation group and the control group was conducted using a repeated measures design analysis of variance.The results were as follows:(1)The comparison of MAP and HR at different time points showed statistically significant differences(P<0.05).(2)There was a statistically significant difference in MAP and HR between the observation group and the control group(P<0.05).The MAP and HR of the observation group were lower,and the hemodynamics were more stable.(3)The comparison of the changing trends of MAP and HR between the two groups showed statistically significant differences(P<0.05).The FLACC score grades of pain during the recovery period in the observation group was higher than that in the control group(P<0.05).The recovery time of spontaneous breathing,the time of eye opening,the time of laryngeal mask removal and the stay time in the anesthesia recovery room in the observation group were all lower than those in the control group(P<0.05).The total incidence of adverse reactions in the observation group was lower than that in the control group(P<0.05).Conclusion The application of afentanil hydrochloride in the induction of intravenous anesthesia in the laparoscopic operation of pediatric hernia can obtain relatively stable hemodynamics,shorten the recovery time of anesthesia and reduce the occurrence of adverse reactions.关键词
疝气/腹腔镜手术/盐酸阿芬太尼/舒芬太尼/小儿/全凭静脉麻醉/麻醉诱导Key words
hernia/laparoscopic surgery/afentanil hydrochloride/sufentanil/children/all intravenous anesthesia/induction of anesthesia分类
医药卫生引用本文复制引用
王静茹,刘兴慧..盐酸阿芬太尼在小儿疝气腹腔镜手术全凭静脉麻醉诱导中的作用[J].中国现代医学杂志,2025,35(21):48-52,5.基金项目
安徽省自然科学基金(No:2308085MC82) （No:2308085MC82）
白求恩公益基金会:恩泽疼痛管理医学研究项目(No:ezmr2023-033) （No:ezmr2023-033）
