中国药房2025，Vol.36Issue(21)：2632-2637,6.DOI:10.6039/j.issn.1001-0408.2025.21.03
石南藤活性部位的化学成分研究
Study on the chemical constituents of the active parts of Piper wallichii
摘要
Abstract
OBJECTIVE To analyze the chemical constituents of the active parts of Piper wallichii.METHODS The petroleum ether-extract fraction was prepared from the methanol extract of P.wallichii.Separation and purification were performed using semi-preparative high-performance liquid chromatography.The structures of the compounds were identified by nuclear magnetic resonance spectroscopy.RESULTS Nineteen compounds were isolated from the petroleum ether-extract fraction from the methanol extract of P.wallichii,identified as 3-acetoxybenzyl benzoate(1),2-acetoxybenzyl benzoate(2),2-methoxybenzyl benzoate(3),3-methoxybenzyl benzoate(4),4-hydroxy-3-methoxybenzyl benzoate(5),3-hydroxybenzyl benzoate(6),benzyl benzoate(7),ganschisandrine(8),lancifolin A(9),(7R,8R,3′R)-7-acetoxy-3′,4′-dimethoxy-3,4-methylenedioxy-6′-oxo-Δ1′,4′,8′-8.3′-lignan(10),(7S,8R,3′S)-Δ8′-3′,6′-dihydro-3′-methoxy-3,4-methylenedioxy-6′-oxo-8.3′,7.O.4′-lignan(11),(7R,8R,3′S)-Δ8′-3′,6′-dihydro-3′-methoxy-3,4-methylenedioxy-6′-oxo-8.3′,7.O.4′-lignan(12),isodihydrofutoquinol A(13),licarin A(14),licarin B(15),2-(2′,5′-dimethoxyphenyl)-3,4-dimethyl-5-(3″,4″-dimethoxyphenyl)-tetrahydrofuran(16),galgravin(17),velutin(18),and piyunin A(19).CONCLUSIONS Compound 1 is a new benzyl benzoate compound.Compounds 3-5,8 and 9 are isolated from the Piper genus for the first time,while compounds 2,6,10-13 and 15-19 are isolated from P.wallichii for the first time.关键词
石南藤/胡椒属/苯甲酸苄酯衍生物/3-乙酰氧基苯甲酸苄酯Key words
Piper wallichii/Piper genus/benzyl benzoate derivative/3-acetoxybenzyl benzoate分类
医药卫生引用本文复制引用
曾玲,胡玉杰,李玲,龚小见,周婵媛,范东生..石南藤活性部位的化学成分研究[J].中国药房,2025,36(21):2632-2637,6.基金项目
国家自然科学基金地区科学基金项目(No.81960787) （No.81960787）
贵州中医药大学第一附属医院中医药(民族医药)传承创新人才团队项目(No.GZYYFY2025007) （民族医药）
李玲全国老药工传承工作室项目(No.国中医药人教函[2025]181号) （No.国中医药人教函[2025]181号）
王建科全国老药工传承工作室项目(No.国中医药人教函[2024]255号) （No.国中医药人教函[2024]255号）
