中国药房2025，Vol.36Issue(21)：2738-2741,4.DOI:10.6039/j.issn.1001-0408.2025.21.21
中药复方药效物质基础分析技术研究进展
Research progress in analytical technologies for characterizing pharmacodynamic substance basis of traditional Chinese medicine compound prescriptions
摘要
Abstract
Traditional Chinese medicine(TCM)compound prescriptions serve as crucial practical embodiments of TCM theoretical frameworks,characterized by their complex multi-component composition and multi-target interactions.The research on the material basis of their pharmacological effects has gradually become the key to promoting the modernization of TCM.In recent years,new ideas and theories regarding the research on pharmacodynamic substance basis of TCM compound prescriptions have been continuously proposed.This review systematically summarizes and reviews analytical techniques such as targeted fishing technology,spectrum-effect relationship analysis,serum pharmacochemistry,network pharmacology,high-throughput screening,and cell membrane chromatography.It is found that these techniques exhibit unique advantages in areas including target-specific analysis,component-pharmacological effect correlation analysis,identification of the material basis in vitro and in vivo,prediction of multi-target mechanisms,efficient screening of active ingredients,and analysis of interactions between cell membrane receptors.These techniques compensate for the shortcomings of traditional research methods,enhance the systematicness and precision of research on pharmacodynamic substance based TCM compound prescriptions,and can provide theoretical support for the promotion and clinical application of TCM compound prescriptions.关键词
中药复方/药效物质/分析技术Key words
traditional Chinese medicine compound prescriptions/pharmacodynamic substance/analytical technology分类
药学引用本文复制引用
袁媛,牛娣,庞欣欣,杜朝阳,王亚男,陈瑞芳..中药复方药效物质基础分析技术研究进展[J].中国药房,2025,36(21):2738-2741,4.基金项目
国家自然科学基金项目(No.82574990,No.82474495) （No.82574990,No.82474495）
河南省医学科技攻关计划省部共建青年项目(No.SBGJ202403050) （No.SBGJ202403050）
河南省研究生教育改革与质量提升工程项目(No.YJS2024KC22) （No.YJS2024KC22）
河南省中医药科学研究专项(No.2024ZY2075) （No.2024ZY2075）
河南省高等学校重点科研项目(No.25A360022) （No.25A360022）
