中国药房2025，Vol.36Issue(21)：2742-2746,5.DOI:10.6039/j.issn.1001-0408.2025.21.22
雷公藤及其活性成分对免疫球蛋白A肾病的作用机制研究进展
Research progress on the mechanisms of Tripterygium wilfordii and its active components on immunoglobulin A nephropathy
摘要
Abstract
Immunoglobulin A nephropathy(IgAN)is a common primary glomerular disease and a frequent cause of chronic renal failure.Tripterygium wilfordii is a traditional Chinese herbal medicine,which possesses the effects of promoting blood circulation,relieving swelling and pain,and dispelling wind and dampness.Modern pharmacological studies have shown that T.wilfordii multiglucoside exhibit anti-inflammatory and immunomodulatory effects,inhibit mesangial cell proliferation,protect podocytes,ameliorate endothelial cell injury,and regulate gut microbiota disturbances.Triptolide also possesses anti-inflammatory and immunomodulatory properties,suppresses mesangial cell proliferation,and protects podocytes.Celastrol demonstrates anti-inflammatory and immunomodulatory functions as well as the ability to improve endothelial cell damage.Through these mechanisms,T.wilfordii and its active components can play a role in alleviating clinical symptoms and delaying disease progression in the treatment of IgAN.Future research should focus on in-depth analysis and mechanistic investigation of these active ingredients,promote high-quality clinical studies,systematically evaluate the synergistic effects among them,and emphasize strategies for reducing toxicity and enhancing efficacy,thereby providing more comprehensive and reliable evidence-based foundations for the clinical treatment of IgAN.关键词
雷公藤/免疫球蛋白A肾病/活性成分/作用机制Key words
Tripterygium wilfordii/immunoglobulin A nephropathy/active ingredients/mechanism of action分类
药学引用本文复制引用
赵沛东,郭闫闫,任相阁,张佳伟,翟文生..雷公藤及其活性成分对免疫球蛋白A肾病的作用机制研究进展[J].中国药房,2025,36(21):2742-2746,5.基金项目
国家自然科学基金项目(No.82274577) （No.82274577）
河南省特色骨干学科中医学学科建设项目(No.STG-ZYX03-202128) （No.STG-ZYX03-202128）
