中国药房2025，Vol.36Issue(21)：2747-2752,6.DOI:10.6039/j.issn.1001-0408.2025.21.23
中药活性成分及复方通过NF-κB通路干预脓毒症相关性急性肾损伤的作用机制
Mechanism of active ingredients and compound formula of traditional Chinese medicine intervening in sepsis-associated acute kidney injury via the NF-κB signaling pathway
摘要
Abstract
Sepsis-associated acute kidney injury(SA-AKI)is an acute kidney injury caused by sepsis,characterized by acute onset,severe progression and high mortality.The abnormal activation of the nuclear factor-κB(NF-κB)signaling pathway can lead to pathological processes such as renal inflammatory cascade reactions,oxidative stress,apoptosis and pyroptosis,and microcirculatory dysfunction,thereby promoting the development of SA-AKI.In recent years,the basic research on the prevention and treatment of SA-AKI with traditional Chinese medicine(TCM)has made significant progress,among which NF-κB plays an important role as a key factor.This article summarizes the research findings over the past few years on active ingredients and compound formula of TCM interventions for SA-AKI via the NF-κB signaling pathway.It elaborates on various active ingredients of TCM,such as flavonoids,phenols,glycosides,terpenoids,quinones and alkaloids,as well as TCM compound formulations including Qihuang jiedu huayu decoction,Huangqi jiuni decoction,and Xuebijing injection,etc.These interventions significantly inhibit renal inflammatory responses,oxidative stress,apoptosis,pyroptosis and microcirculatory dysfunction by regulating multiple NF-κB-mediated signaling pathways,such as Toll-like receptor 4/myeloid differentiation primary response protein 88/NF-κB,sirtuin 1/NF-κB,NF-κB/NOD-like receptor family pyrin domain-containing protein 3,thereby alleviating SA-AKI and improving renal function.关键词
脓毒症/急性肾损伤/核因子κB/中药/活性成分/复方Key words
sepsis/acute kidney injury/nuclear factor-κB/traditional Chinese medicine/active ingredients/compound formula分类
药学引用本文复制引用
向敏,陈思源..中药活性成分及复方通过NF-κB通路干预脓毒症相关性急性肾损伤的作用机制[J].中国药房,2025,36(21):2747-2752,6.基金项目
四川省自然科学基金面上项目(No.2025ZNSFSC0666) （No.2025ZNSFSC0666）
