中国中西医结合儿科学2025，Vol.17Issue(5)：382-386,5.DOI:10.20274/j.cnki.issn.1674-3865.2025.05.004
肠道菌群参与新生儿黄疸的机制及研究进展
Mechanism and research progress of gut microbiota involved in neonatal jaundice
摘要
Abstract
The neonatal period represents a critical period for gut microbiota colonization and immune system development,exerting profound impacts on individual health.Neonatal jaundice is the most common clinical manifestation during this period,and its pathological process is closely associated with the imbalance of bilirubin metabolism.Gut microbiota plays a pivotal role in bilirubin metabolism through regulating the enterohepatic circulation.This review systematically reviews the composition and development of neonatal gut microbiota,provides an in-depth analysis of its role in bilirubin metabolism and its effects on serum bilirubin levels,and elaborates in detail on the potential mechanisms of enzymatic reactions,immune regulation and intestinal barrier function that affect bilirubin metabolism.The aim is to provide theoretical basis for clinical prevention and treatment of neonatal jaundice,thereby promoting the healthy development of neonates.关键词
新生儿黄疸/肠道菌群/肠肝循环/双歧杆菌Key words
Neonatal jaundice/Gut microbiota/Enterohepatic circulation/Bifidobacterium分类
医药卫生引用本文复制引用
彭鑫,王雨倩,杨柳..肠道菌群参与新生儿黄疸的机制及研究进展[J].中国中西医结合儿科学,2025,17(5):382-386,5.基金项目
国家自然科学基金项目(82201896) National Natural Science Foundation of China Project(No.82201896) （82201896）
