中国中西医结合儿科学2025，Vol.17Issue(5)：397-401,5.DOI:10.20274/j.cnki.issn.1674-3865.2025.05.007
基于核因子-κB探究肾驻留细胞在狼疮性肾炎中的作用机制
Study on the mechanism of action of renal resident cells in lupus nephritis based on NF-κB
黄鸿勋 1李伟伟2
作者信息
- 1. 530022 南宁,广西中医药大学
- 2. 广西中医药大学第一附属医院儿科
- 折叠
摘要
Abstract
Lupus nephritis(LN)is an immunocomplex nephritis caused by systemic lupus erythematosus(SLE)involving the kidneys.The main manifestation of LN is the deposition of autoantibodies and their immunocomplexes in the kidneys,which triggers a chronic inflammatory infiltration and the gradual destruction of the structure and function of the kidneys.The renal resident cells play a crucial role in this process.Recent studies have shown that nuclear factor-kappa B(NF-κB)can regulate the gene expression of multiple cytokines,growth factors and adhesion molecules in the progression of inflammation,such as the expression of monocyte chemoattractant protein-1 and granulocyte-macrophage colony-stimulating factors in mesangium and glomerular epithelial cells.NF-κB is closely related to the development of LN and plays a unique role in targeting and regulating the biological responses of renal resident cells,including renal mesangial cells,podocytes and tubular epithelial cells.Against this background,this article reviews the relationship between NF-κB and renal resident cells and their role in the pathogenesis of LN,with an aim to gain a deeper understanding of the underlying cellular and molecular mechanisms involved in LN and provide theoretical references for application in LN prevention and treatment.关键词
狼疮性肾炎/核因子-κB通路/肾驻留细胞/作用机制Key words
Lupus nephritis/NF-κB pathway/Renal resident cells/Mechanism of action分类
医药卫生引用本文复制引用
黄鸿勋,李伟伟..基于核因子-κB探究肾驻留细胞在狼疮性肾炎中的作用机制[J].中国中西医结合儿科学,2025,17(5):397-401,5.
