中国医药科学2025，Vol.15Issue(19)：66-70,5.DOI:10.20116/j.issn2095-0616.2025.19.14
山蜡梅叶中山蜡梅碱和蜡梅碱对小鼠的急性毒性研究
Study on acute toxicity of chimonanthamine and calycanthine from the leaves of Chimonanthus nitens to mice
摘要
Abstract
Objective To study the acute toxicity of chimonanthamine and calycanthine from the leaves of Chimonanthus nitens to mice.Methods The alkaloids in the leaves of Chimonanthus nitens were extracted and separated,and the chimonanthamine and calycanthine were obtained.Mice were given different doses of chimonanthamine and calycanthine once a day,and the toxicity and 14-day survival of the mice were recorded.Results No mice died when the concentration of chimonanthine was 138.60-69.30 mg/kg,but some mices died when the concentration of calycanthine was 88.25-45.18 mg/kg,and the mortality rate decreased with the decrease of calycanthine concentration,and no mice died when the concentration was reduced to 36.15 mg/kg.The LD50 of calycanthine was 50.8 mg/kg by DAS 30 software,and the 95%confidence interval was 45.94-56.14 mg/kg.Conclusion Calycanthine exhibits certain toxicity to mice,while chimonanthine has no obvious toxicity in the experimental dose range.关键词
山蜡梅叶/山蜡梅碱/蜡梅碱/急性毒性试验Key words
Chimonanthus nitens/Chimonanthine/Calycanthine/Acute toxicity test分类
医药卫生引用本文复制引用
肖草茂,李春红,马员宇,伍锡栋..山蜡梅叶中山蜡梅碱和蜡梅碱对小鼠的急性毒性研究[J].中国医药科学,2025,15(19):66-70,5.基金项目
江西省药品监督管理局科研项目(2020JS23). （2020JS23）
