中国肿瘤生物治疗杂志2025，Vol.32Issue(10)：1065-1070,6.DOI:10.3872/j.issn.1007-385x.2025.10.009
外周免疫功能状态在肺癌转移"正虚"评估中的临床价值
Clinical value of peripheral immune function status in the assessment of'Deficiency of Vital Qi'in lung cancer metastasis
摘要
Abstract
Objective:To investigate the association between peripheral immune function status and lung cancer metastasis,and to identify peripheral blood immune biomarkers for'Deficiency of Vital Qi'assessment in lung cancer metastasis.Methods:A retrospective analysis was conducted on peripheral blood immune markers collected before treatment from lung cancer patients admitted into Shanghai Municipal Hospital of Traditional Chinese Medicine,affiliated to Shanghai University of Traditional Chinese Medicine,between March 2023 and April 2025.Patients were categorized into the non-metastatic and the metastatic groups based on the presence of distant metastasis,and the differences in the expressions of immune cells and cytokines between groups were compared.Peripheral blood immune markers with P<0.05 in univariate analysis were incorporated into a multivariate binary logistic regression model to identify independent predictors of lung cancer metastasis.Results:A total of 193 lung cancer patients were included(101 in the non-metastatic group and 92 in the metastatic group).There were no statistically significant differences between the two groups in terms of gender,age,smoking history,drinking history,or pathological type(all P>0.05).Univariate analysis revealed significant differences in multiple immune markers between the non-metastatic and metastatic groups(all P<0.05),including:lymphocyte count,CD3+,CD4+,and CD8+T,CD19+B cells,absolute counts of CD3-CD16+CD56+NK cells,percentages of Treg cells,CD8+CD28+Treg cells,G-MDSC,and CD3-CD16+CD56+dim NK cells,and levels of cytokine IL-1β,IL-6,and IL-10.Binary logistic regression analysis of differential indicators suggested that the percentage of Treg cells and CD8+CD28+Treg cells in peripheral blood were independent predictors of distant metastasis in lung cancer(OR=1.193,95%CI[1.047,1.36],P<0.01;OR=0.978,95%CI[0.957,0.999],P<0.05).Conclusion:Peripheral blood immune dysfunction is the biological basis for'qi deficiency'in lung cancer metastasis.This study quantitatively demonstrates the correlation between peripheral immune function status and lung cancer metastasis,providing empirical evidence for the theories of'qi deficiency and hidden toxicity'and'metastatic state of tumors'.关键词
肺癌/远处转移/肿瘤转移态/正虚/外周血/免疫标志物Key words
lung cancer/distant metastasis/the metastatic state of tumors/Deficiency of Vital Qi/peripheral blood/immune marker分类
临床医学引用本文复制引用
许帆,陆鑫熠,刘瑶,周奕阳,吴建春,骆莹滨,李明花,史文翡,崔亚静,上官文姬,李雁,田建辉,刘佑俊,程振洋,阙祖俊,罗斌,杨蕴,姚嘉良,姚望..外周免疫功能状态在肺癌转移"正虚"评估中的临床价值[J].中国肿瘤生物治疗杂志,2025,32(10):1065-1070,6.基金项目
国家自然科学基金(No.82174245) （No.82174245）
第五批全国中医临床优秀人才研修项目[No.国中医药人教函[2022]1号] （）
上海市卫生健康领军人才(No.2022LJ014) （No.2022LJ014）
上海申康医院发展中心第二轮《促进市级医院临床技能与临床创新三年行动计划》研究型医师创新转化能力培训项目(No.SHDC2023CRD01) （No.SHDC2023CRD01）
2024年度上海市卫生健康委员会临床研究专项(No.20244Y0166) （No.20244Y0166）
上海市2024年度"科技创新行动计划"启明星培育(扬帆专项)(No.24YF2741300) （扬帆专项）
