中国中医急症2025，Vol.34Issue(10)：1577-1581,5.DOI:10.3969/j.issn.1004-745X.2025.10.003
脓毒症慢重症期患者的中医证候分布及预后相关性分析
Traditional Chinese Medicine Syndrome Distribution and Its Association with Prognosis in Patients During the Chronic Critical Illness Phase of Sepsis
摘要
Abstract
Objective:To observe the distribution of traditional Chinese medicine(TCM)syndrome distribution and their association with prognosis in patients during the chronic critical illness phase of sepsis.Methods:Clini-cal data were collected from patients diagnosed with sepsis and hospitalized for≥8 days in the Intensive Care Unit(ICU)or Emergency Intensive Care Unit(EICU)of Xiyuan Hospital,China Academy of Chinese Medical Scienc-es,between January 1,2020,and December 1,2024.Syndrome elements were calculated,TCM syndrome patterns were determined,and cluster analysis was applied to validate syndrome pattern distribution.Patients were divided into survival and non-survival groups based on 90 day outcomes.Differences in demographic data,laboratory pa-rameters,major syndrome patterns,SOFA scores,and APACHEⅡ scores between the two groups were compared.Cox regression analysis was performed to identify factors influencing prognosis,and ROC curves were constructed to evaluate predictive performance.Results:The predominant TCM syndrome elements in the chronic critical phase of sepsis involved the lung and spleen,along with turbid phlegm and qi deficiency.Major syndrome patterns included syndrome of turbid phlegm obstructing lung,syndrome of turbid phlegm accumulating in the lung,and de-ficiency of both qi and blood as well as yin and yang.Overall,most patients presented with complex syndromes characterized by a mixture of deficiency and excess.An APACHEⅡ score>20.5 was identified as a potential risk factor for 90-day mortality.Conclusion:APACHEⅡ score may serve as an early warning indicator for poor prog-nosis in patients with chronic critical illness due to sepsis.Tonifying qi and strengthening vital qi could be a key therapeutic strategy in the TCM management of these patients.关键词
脓毒症/慢重症/证素/预后/回归分析Key words
Sepsis/Chronic critical illness/Syndrome elements/Prognosis/Regression analysis分类
医药卫生引用本文复制引用
徐建兴,易亮,李洁,李春,茹江丽,杨志旭..脓毒症慢重症期患者的中医证候分布及预后相关性分析[J].中国中医急症,2025,34(10):1577-1581,5.基金项目
国家自然科学基金项目(82174361) （82174361）
中国中医科学院科技创新工程重大攻关项目(CI2021A02908) （CI2021A02908）
