中国中医急症2025，Vol.34Issue(10)：1608-1611,1616,5.DOI:10.3969/j.issn.1004-745X.2025.10.009
加味二陈汤联合西医常规治疗支气管扩张症急性加重期(痰热蕴肺证)的临床研究
Clinical Observation of Modified Erchen Decoction Combined with Conventional Western Medicine in Treating Acute Exacerbation of Bronchiectasis with Syndrome of Phlegm-Heat Accumulating in the Lung
摘要
Abstract
Objective:To observe the clinical efficacy and safety of Modified Erchen Decoction in patients with acute exacerbation of bronchiectasis with syndrome of phlegm-heat accumulating in the lung.Methods:A total of 112 eligible patients with acute exacerbation of bronchiectasis and syndrome of phlegm-heat in the lung were ran-domly assigned to a treatment group and a control group,with 56 patients in each group.The control group re-ceived conventional western medical treatment,while the treatment group received Modified Erchen Decoction in addition to the control group's regimen.The treatment course was 7 days.Outcomes observed before and after treatment included traditional Chinese medicine(TCM)syndrome efficacy,total TCM syndrome score,COPD As-sessment Test(CAT)score,serum inflammatory markers[white blood cell count(WBC),neutrophil count(NE),neutrophil-to-lymphocyte ratio(NLR),C-reactive protein(CRP),erythrocyte sedimentation rate(ESR),procalcito-nin(PCT),interleukin-6(IL-6)],blood gas analysis indices(PaO2,PaCO2),and adverse reactions.Results:The to-tal clinical effective rate in the treatment group was 92.86%,which was significantly higher than 85.71%in the control group(P<0.05).Before treatment,there were no significant differences between the two groups in total TCM syndrome score,CAT score,serum inflammatory markers(WBC,NE,NLR,CRP,ESR,PCT,IL-6),or blood gas analysis indices(PaO2,PaCO2)(P>0.05).After treatment,both groups showed reduced total TCM syndrome scores and CAT scores,with significantly greater reductions in the treatment group compared with the control group(P<0.05).Serum inflammatory marker levels decreased in both groups after treatment,with more significant re-ductions in the treatment group(P<0.05).PaO2 increased and PaCO2 decreased in both groups after treatment,with better improvements in the treatment group(P<0.05).No adverse reactions occurred during the observation period.Conclusion:Adding Modified Erchen Decoction to conventional western medical treatment effectively im-proves clinical symptoms in patients with acute exacerbation of bronchiectasis and syndrome of phlegm-heat accu-mulating in the lung,reduces serum levels of inflammalory,improves indices of blood gas analysis,and enhances overall clinical efficacy.关键词
支气管扩张症/急性加重期/痰热蕴肺证/加味二陈汤/临床观察Key words
Bronchiectasis/Acute exacerbation/Syndrome of phlegm-heat accumulating in the lung/Modified Erchen Decoction/Clinical observation分类
医药卫生引用本文复制引用
宋坤珊,钟云青,冯海威,吴思沁,马浩挺,刘雯雯,蓝彩银..加味二陈汤联合西医常规治疗支气管扩张症急性加重期(痰热蕴肺证)的临床研究[J].中国中医急症,2025,34(10):1608-1611,1616,5.基金项目
国家自然科学基金地区科学基金项目(82260903) （82260903）
广西壮族自治区中医药管理局广西中医药适宜技术开发与推广项目(GZSY23-49) （GZSY23-49）
广西中医药大学引进博士科研启动基金项目(2020BS033) （2020BS033）
