中国卒中杂志2025，Vol.20Issue(10)：1270-1276,7.DOI:10.3969/j.issn.1673-5765.2025.10.009
甘油三酯-葡萄糖指数在烟雾病患者中的特征分析:1项病例对照研究
Analysis of Triglyceride-Glucose Index Characteristics in Patients with Moyamoya Disease:A Case-Control Study
摘要
Abstract
Objective To investigate the relationship between the triglyceride-glucose(TyG)index and moyamoya disease(MMD)as well as its clinical manifestations. Methods Patients with MMD who were hospitalized in the Department of Neurosurgery,Beijing Tiantan Hospital,Capital Medical University,and healthy controls during the same period were retrospectively and consecutively enrolled between August 2022 and May 2024.Propensity score matching for sex and age was performed,and the matched MMD patients were assigned to the MMD group,while the healthy controls were assigned to the control group.Demographic data,laboratory test results,and imaging data were collected for the MMD patients,and the TyG index was calculated.Logistic regression analysis was performed to explore the relationship between the TyG index and Suzuki stages as well as clinical manifestations of MMD. Results A total of 205 patients with MMD and 231 healthy controls were enrolled.After propensity score matching,187 patients in the MMD group and 187 healthy controls were finally matched.The TyG index was higher in the MMD group compared to the control group[8.54(8.12-8.95)vs.8.05(7.81-8.42),P＜0.001].There were no significant differences in the TyG index among different Suzuki stages and clinical manifestations within the MMD group.Correlation analysis showed that the TyG index was positively correlated with age in both the MMD group(r=0.31,P＜0.001)and the control group(r=0.28,P＜0.001).Moreover,within the same age range,the TyG index was higher in the MMD group than in the control group.Logistic regression analysis showed that elevated TyG index was not significantly associated with Suzuki stages or clinical manifestations. Conclusions The TyG index can reflect the glucose and lipid metabolic disturbances associated with insulin resistance in patients with MMD.In the future,it may be used to assess individual metabolic characteristics of MMD,providing a reference for personalized precision interventions.关键词
烟雾病/卒中/甘油三酯-葡萄糖指数Key words
Moyamoya disease/Stroke/Triglyceride-glucose index分类
临床医学引用本文复制引用
孙旭东,曾超凡,陈颢元,李昊,张岩,张谦..甘油三酯-葡萄糖指数在烟雾病患者中的特征分析:1项病例对照研究[J].中国卒中杂志,2025,20(10):1270-1276,7.基金项目
北京市属医院科研培育计划(PX2024022) （PX2024022）
