中国畜禽种业2025，Vol.21Issue(10)：16-26,11.
体细胞克隆胚胎发育效率影响因素及其改进措施
Influencing Factors and Improvement Measures of Development Efficiency of Somatic Cell Cloned Embryos
摘要
Abstract
Animal somatic cell nuclear transfer technology holds significant potential for the replication and propagation of superior livestock breeds,the conservation of endangered species,the generation of genetically modified animals,and the advancement of human disease therapies.Nevertheless,its application remains constrained by challenges such as low cloning efficiency and high technical complexity.In this paper,we briefly review the main development history of animal somatic cell nuclear transfer technol-ogy,and briefly introduce the general operation process of animal somatic cell cloning.Afterwards,by summarising the existing re-search results,the main factors affecting the developmental efficiency of cloned embryos are classified as"complex and delicate cloning techniques","suboptimal oocyte quality"and"epigenetic reprogramming and gene expression errors",and the solutions that have been developed are summarized,so that more people can understand the technology and promote its innovative development and application.关键词
动物/体细胞克隆/胚胎/发育效率Key words
Animal/Somatic cell nuclear transfer(SCNT)/Embryo/Developmental efficiency分类
农业科技引用本文复制引用
叶鸥颉,董亚铮,洪林君,李紫聪..体细胞克隆胚胎发育效率影响因素及其改进措施[J].中国畜禽种业,2025,21(10):16-26,11.基金项目
广东省农业农村厅种业振兴项目(2024-XPY-00-004). （2024-XPY-00-004）
