浙江大学学报（医学版）2025，Vol.54Issue(5)：592-601,10.DOI:10.3724/zdxbyxb-2025-0430
皮肤纤维化中细胞代谢重编程研究进展
Research progress on cellular metabolic reprogramming in skin fibrosis
摘要
Abstract
Skin fibrosis is primarily characterized by excessive fibroblasts proliferation and aberrant extracellular matrix accumulation,leading to pathological conditions such as hypertrophic scars,keloids,and systemic sclerosis.This dynamic and complex process involves intricate interactions among various resident skin cells and inflammatory cells,ultimately resulting in extracellular matrix deposition and even invasive growth.The maintenance of cellular phenotypes and functions relies on dynamic metabolic responses,and cellular signal transduction is closely coupled with metabolic processes.Given that the coupling of cell metabolism and signaling in the skin fibrosis microenvironment plays a critical role in inflammatory responses and fibrotic activation,modulation of these metabolic pathways may offer novel therapeutic strategies for inhibiting or even reversing the progression of skin fibrosis.This review systematically summarizes the metabolic characteristics of various cell types involved in skin fibrosis,with a focus on core metabolic reprogramming mechanisms such as hyperactive glycolysis,dysregulated fatty acid metabolism,cellular metabolic dysfunction and dysregulated mTOR/AMPK signaling.Furthermore,potential intervention strategies targeting these metabolic pathways are explored,thereby providing new research perspectives for the treatment of skin fibrosis.关键词
皮肤疾病/纤维化/代谢重编程/成纤维细胞/糖酵解/脂肪酸代谢/mTOR/AMPK信号通路/综述Key words
Skin diseases/Fibrosis/Metabolic reprogramming/Fibroblasts/Glycolysis/Fatty acid metabolism/mTOR/AMPK signal pathway/Review分类
医药卫生引用本文复制引用
钱姝桐,戴思雅,郭纯逸,徐靖宏..皮肤纤维化中细胞代谢重编程研究进展[J].浙江大学学报（医学版）,2025,54(5):592-601,10.基金项目
国家自然科学基金(82472553) （82472553）
浙江省自然科学基金(LMS25H150001) This study was supported by National Natural Science Foundation of China(82472553)and Natural Science Foundation of Zhejiang Province(LMS25H150001). （LMS25H150001）
