中国中西医结合杂志2025，Vol.45Issue(10)：1207-1214,8.DOI:10.7661/j.cjim.20250717.086
原发性干燥综合征不同病程患者中医证型及疾病活动度特点
Chinese Medicine Syndrome Types and Disease Activity Characteristics of Patients with Primary Sjögren's Syndrome with Different Disease Duration
摘要
Abstract
Objective To investigate the variations of Chinese medicine(CM)syndrome types and disease activity in patients with primary Sjögren's syndrome(pSS)of different disease durations.Methods A cross-sectional study was performed including patients with pSS who were admitted to China-Japan Friendship Hospital from January 2015 to September 2023.Patients were stratified by disease duration into short-duration(＜5 years)and long-duration(≥5 years)groups.The differences of demographic variables,clinical manifestations,and the distribution of CM syndrome types,glandular involvement,and disease activity[quantified with the EULAR Sjögren's Syndrome Disease Activity Index(ESSDAI)]were compared between the two disease duration groups.Besides,patients were assigned to 2-year disease-duration intervals to analyze the trend of CM syndrome type and disease activity with the disease duration.Subsequently,participants were reclassified into low-activity(ESSDAI＜5)and moderate-to-high-activity(ESSDAI≥5)groups to analyze CM syndrome types distribution and glandular involvement across disease activity levels.Results A total of 1 203 patients with pSS were included,comprising 724 patients(60.2％)with short disease duration and 479 patients(39.8％)with long disease duration.Patients with long disease duration were more likely to report dry mouth and eyes,and the prevalence of these symptoms showed an increasing trend with longer disease duration(P＜0.05).Yin fluids deficiency pattern was the most common syndrome type of pSS,but no significant difference was observed between the two disease durations groups(P＞0.05).Patients with long disease duration were significantly more likely to present with Qi and Yin deficiency pattern(57.2％vs.42.3％,OR=1.723,95％CI:1.357-2.188,P＜0.001)and dryness-dampness interplay pattern(53.0％vs.35.4％,OR=1.947,95％CI:1.532-2.474,P＜0.001)than patients with short disease duration,and the proportion of the two patterns showed an increasing trend with the increase of the disease duration(Ptrend＜0.05).The proportion of patients with high disease activity was significantly higher in the short disease duration group compared to the long disease duration group(29.4％vs.23.8％,P＜0.05),and the proportion of high disease activity showed a decreasing trend with the increase of disease duration(x2=6.605,Ptrend＜0.05).Patients with Yin deficiency-induced internal heat pattern(OR=2.555,95％CI:2.555-5.600,P＜0.001)and dryness and blood stasis pattern(OR=1.869,95％CI:1.347-2.592,P＜0.001)had a higher proportion of high activity.Conclusions Yin fluids deficiency is pervasive in pSS.Qi and Yin deficiency pattern and dryness-dampness interplay pattern are identified as the two core pathogenic factors of pSS.As disease duration increases,the while prevalence of dry mouth and eyes,Qi and Yin deficiency pattern,and dryness-dampness interplay pattern increase,the proportion of patients with high disease activity decreases.关键词
干燥综合征/病程/中医证型/疾病活动度/中西医结合Key words
Sjogren's syndrome/disease duration/Chinese medicine syndrome types/disease activity/integrative medicine引用本文复制引用
张燕,陶庆文,陈嘉琪,雷淳心,杨建英,张曦亚,廖佳禾,吴子华,黄子玮,罗静..原发性干燥综合征不同病程患者中医证型及疾病活动度特点[J].中国中西医结合杂志,2025,45(10):1207-1214,8.基金项目
首都卫生发展科研专项项目(No.首发2024-1-4065) （No.首发2024-1-4065）
中日友好医院"菁英计划"人才培育工程资助(No.ZRJY2024-GG08) （No.ZRJY2024-GG08）
北京中医药科技发展基金项目(No.BJZYQN-2023-04) （No.BJZYQN-2023-04）
中华中医药学会风湿病分会青年培英计划(No.202327-007) （No.202327-007）
北京中医药大学自主课题(No.ZJKT2024060) （No.ZJKT2024060）
