中西医结合肝病杂志2025，Vol.35Issue(10)：1232-1237,6.DOI:10.3969/j.issn.1005-0264.2025.010.009
结合中医证型的肝癌经导管动脉化疗栓塞术后栓塞综合征危险因素分析
Analysis of risk factors for embolic syndrome after transcatheter arterial chemoembolization of liver cancer combined with traditional Chinese medicine syndrome types
摘要
Abstract
Objective:To explore the factors related to post-embolic syndrome(PES)after hepatic arterial chemoembolization(TACE)in Hepatocellular carcinoma(HCC)based on different traditional Chinese medicine(TCM)syndrome types,so as to provide a reference for improving the safety of TACE.Methods:The clinical data of HCC patients treated with TACE in our hospital from 2020 to 2023 were prospectively collected.Before the operation,two TCM professional physicians with senior professional titles performed TCM syndrome diagnosis.Clinical data including of age,gender,history of chronic liver disease,tumor stage,child-pugh grade,Eastern Cooperative Oncology Group(ECOG)score,liver cirrhosis status,preoperative active tumor,previous tumor treatment,the way of TACE treatment.The manifestations of embolic syndrome within 3 days after TACE surgery,and the tumor evaluation of solid tumor evaluation(mRESIST)after TACE surgery.According to the grade of PES within three days after TACE,the patients were divided into no or mild PES group(PES score 0-1)and moderate to severe PES group(PES score 2-4),and the influencing factors of moderate to severe PES were analyzed.Results:Compared with the qi stagnation and blood stasis pattern and the liver and kidney yin deficiency pattern,there was no statistical difference in the tumor characteristics between the three groups(P>0.05)in the liver stagnation and spleen deficiency syndrome,preoperative ECOG score,previous TACE,ablation therapy,and targeted drug therapy in patients with primary liver cancer(P<0.05).There were statistically significant differences in the occurrence of pain and PES syndrome after TACE with the pattern of liver and kidney yin deficiency and liver depression and spleen deficiency(P<0.05).Qi stagnation and blood stasis syndrome,previous tumor resection,and tumor≥5 cm were independent risk factors for moderate to severe PES after TACE(P<0.05).Conclusion:Patients with liver depression and spleen deficiency syndrome experience more treatment methods,and qi stagnation and blood stasis syndrome is the most common syndrome type of primary liver cancer.Qi stagnation and blood stasis pattern,tumor resection,and tumor≥of 5 cm were independent risk factors for moderate to severe PES after exacerbation of TACE.关键词
原发性肝癌/肝动脉化疗栓塞术/栓塞后综合征Key words
TCM syndrome type/hepatocellular carcinoma/transhepatic arterial chemotherapy and embolization/post-embolization syndrome分类
医药卫生引用本文复制引用
阮梅,夏磊,黄倩,陈凯伟,李军军,方坚..结合中医证型的肝癌经导管动脉化疗栓塞术后栓塞综合征危险因素分析[J].中西医结合肝病杂志,2025,35(10):1232-1237,6.基金项目
福建省中青年教师教育科研项目(No.JAT210143) （No.JAT210143）
