中医药信息2025，Vol.42Issue(10)：46-53,8.DOI:10.19656/j.cnki.1002-2406.20251009
基于隐结构模型和关联规则分析晚期胃癌治疗的方药规律
Analysis of Formulae Patterns for Advanced Gastric Cancer Treatment Based on Latent Structure Model and Association Rules
摘要
Abstract
Objective:To explore Formulae patterns for advanced gastric cancer(AGC)treatment using latent structure model and association rules,providing theoretical support for clinical syndrome differentiation and guideline development.Methods:Systematic searches were conducted in CNKI,Wanfang,VIP,and SinoMed databases to identify and select literature on herbal Formulas for AGC.A database was established using Microsoft Excel 2019.Herbs with frequency>4%were analyzed through latent structure modeling(Lantern 5.0)and association rules(Rstudio),combined with frequency structure model to summarize formulae patterns.Results:217 formulaes involving 218 single herbs(2 555 total applications)were included.High frequency herbs included Atractylodis Macrocephalae Rhizoma,Poria,Astragali Radix,and Codonopsis Radix,primarily tonifying deficiency herbs.Latent structure analysis identified 14 latent variables,28 latent classes,6 comprehensive clustering models,and 15 core formulas,revealing common AGC syndromes:spleen deficiency with dampness accumulation,spleen stomach deficiency cold,stomach yin deficiency,spleen deficiency with food stagnation,liver stomach disharmony,and blood stasis toxin accumulation.Association rules yielded 46 strong correlations,with highest support for Poria Atractylodis Macrocephalae Rhizoma and highest confidence for Codonopsis Radix Poria Astragali Radix Citri Reticulatae Pericarpium-Atractylodis Macrocephalae Rhizoma.Conclusion:AGC manifests as deficiency excess complex with core pathogenesis of"deficiency","stagnation"and"stasis"closely related to spleen,lung and stomach.Treatment should prioritize spleen stomach fortification and strengthening healthy qi while eliminating pathogens,supplemented by syndrome-specific approaches including organ regulation,qi rectification,heat clearing,and stasis resolving therapies.关键词
晚期胃癌/隐结构/关联规则/用药规律Key words
Advanced gastric cancer/Latent structure/Association rules/Medication patterns引用本文复制引用
陈永孟,丁立山,马梁浩,王聪梅,邢作英,陈清亮..基于隐结构模型和关联规则分析晚期胃癌治疗的方药规律[J].中医药信息,2025,42(10):46-53,8.基金项目
国家自然科学基金项目(81803944) （81803944）
河南省医学科技攻关计划联合共建项目(LHGJ20240648) （LHGJ20240648）
郑州市医疗卫生领域科技创新指导计划项目(2024YLZDJH056) （2024YLZDJH056）
