Fundamental Research2025，Vol.5Issue(5)：P.1920-1929,10.DOI:10.1016/j.fmre.2025.03.006
Tumor suppressor protein-inspired peptide for siRNA delivery and synergistic cancer therapy
Julien Milon Essola 1Haiyin Yang 2Wenjing Liu 3Abid Hussain 2Abid Naeem 2Huining He 4Stefan Barth 5Zhuoran Wang 6Kelong Fan 6Mengjie Zhang 7Mengliang Zhu 8Xing-Jie Liang 8Yuanyu Huang7
作者信息
- 1. School of Life Science,Advanced Research Institute of Multidisciplinary Science,Aerospace Center Hospital,Key Laboratory of Molecular Medicine and Biotherapy,Key Laboratory of Medical,Molecule Science and Pharmaceutics Engineering,Beijing Institute of Technology,Beijing 100081,China CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety,CAS Center for Excellence in Nanoscience,National Center for Nanoscience and Technology of China,Zhongguancun,Beijing 100190,China University of Chinese Academy of Sciences,Beijing 100049,China
- 2. School of Life Science,Advanced Research Institute of Multidisciplinary Science,Aerospace Center Hospital,Key Laboratory of Molecular Medicine and Biotherapy,Key Laboratory of Medical,Molecule Science and Pharmaceutics Engineering,Beijing Institute of Technology,Beijing 100081,China
- 3. Department of Pharmacology,Beijing Chest Hospital,Capital Medical University/Beijing Key Laboratory of Drug Resistance Tuberculosis Research,Beijing Tuberculosis and Thoracic Tumor Research Institute,Beijing 101149,China
- 4. Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics,International Joint Laboratory of Ocular Diseases,School of Pharmacy,School of Biomedical Engineering and Technology,Tianjin Medical University,Tianjin 300070,China
- 5. South African Research Chair in Cancer Biotechnology,Institute of Infectious Disease and Molecular Medicine(IDM),Department of Integrative Biomedical Sciences,Faculty of Health Sciences,University of Cape Town,Cape Town 7925,South Africa
- 6. CAS Engineering Laboratory for Nanozyme,Key Laboratory of Protein and Peptide Pharmaceutical,Institute of Biophysics,Chinese Academy of Sciences,Beijing 100101,China
- 7. School of Life Science,Advanced Research Institute of Multidisciplinary Science,Aerospace Center Hospital,Key Laboratory of Molecular Medicine and Biotherapy,Key Laboratory of Medical,Molecule Science and Pharmaceutics Engineering,Beijing Institute of Technology,Beijing 100081,China Advanced Research Institute of Multidisciplinary Science,Beijing Institute of Technology,Zhuhai 519088,China Zhengzhou Research Institute,Beijing Institute of Technology,Zhengzhou 450040,China
- 8. CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety,CAS Center for Excellence in Nanoscience,National Center for Nanoscience and Technology of China,Zhongguancun,Beijing 100190,China University of Chinese Academy of Sciences,Beijing 100049,China
- 折叠
摘要
关键词
RNA interference/Cells penetrating peptide/p16 minimal inhibitory sequence/Cancer/Polo-like kinase 1/Apoptosis分类
医药卫生引用本文复制引用
Julien Milon Essola,Haiyin Yang,Wenjing Liu,Abid Hussain,Abid Naeem,Huining He,Stefan Barth,Zhuoran Wang,Kelong Fan,Mengjie Zhang,Mengliang Zhu,Xing-Jie Liang,Yuanyu Huang..Tumor suppressor protein-inspired peptide for siRNA delivery and synergistic cancer therapy[J].Fundamental Research,2025,5(5):P.1920-1929,10.基金项目
supported by the National Natural Science Founda-tion of China(32101148,32171394,82102204) （32101148,32171394,82102204）
Beijing Nova Program(Interdisciplinary Cooperation Project)from Beijing Municipal Science&Technology Commission(20220484207) （Interdisciplinary Cooperation Project）
National Key Research&Development Program of China(2021YFA1201000,2021YFE0106900,2023YFC2605003) （2021YFA1201000,2021YFE0106900,2023YFC2605003）
National Natural Science Foundation of China(NSFC)key project(32030060) （NSFC）
NSFC international collaboration key project(51861135103) （51861135103）
the Science Fund for Creative Research Groups of Nature Science Foundation of Hebei Province(B2021201038). （B2021201038）
