安徽工程大学学报2025，Vol.40Issue(4)：1-9,40,10.
酸敏型ZIF-8负载辣椒素/NAADP载药体系的构建及其抗肿瘤研究
Construction of Acid-sensitive ZIF-8 Supported Capsaicin/NAADP Drug Delivery System and its Anti-tumor Study
摘要
Abstract
Ca2+overload therapy has attracted more and more attention in the field of oncology because of its good efficacy and little side effects.however,the regulation of calcium homeostasis in cancer cells,the lack of calcium in tumor cells and the low efficiency of calcium entry into tumor cells limit its curative effect,which leads to the unsatisfactory therapeutic effect.A nano-drug loading system CAP/NAADP@ZIF-8-FA which can release acid-sensitive and magnify calcium overload was constructed,and its particle size was about 280 nm.The drug loading of capsaicin(CAP)was 20.1±1.14%,and that of nicotinic acid dinucleotide phosphate(NAADP)was 8.0±0.48%,which had obvious characteristics of drug acid sensitive release.The intracellular Ca2+content of human hepatocellular carcinoma(HepG2)cells treated with CAP/NAADP@ZIF-8-FA was about 6 times higher than that of normal cells.When the concentration of CAP/NAADP@ZIF-8-FA nanoparticles was 320 μg/mL,the inhibition rate of HepG2 cells was more than 89%,and there was no obvious toxicity to normal cells.The anti-tumor activity of CAP/NAADP@ZIF-8-FA nano-drug loading system was significantly higher than that of capsaicin alone.关键词
辣椒素/烟酸腺嘌呤二核苷酸磷酸/沸石咪唑框架-8/钙超载/抗肿瘤Key words
capsaicin/NAADP/ZIF-8/calcium overload/antitumor分类
化学引用本文复制引用
郜远,郑鹏,李兴,崔婷,许飞扬,陶玉贵..酸敏型ZIF-8负载辣椒素/NAADP载药体系的构建及其抗肿瘤研究[J].安徽工程大学学报,2025,40(4):1-9,40,10.基金项目
安徽省高校自然科学研究项目(KJ2021A0511) （KJ2021A0511）
安徽省重点研究和开发计划(2022i01020002) （2022i01020002）
皖南医学院青年拔尖人才计划项目(wyqnyx202005) （wyqnyx202005）
安徽工程大学科研项目(Xjky2022089、2022YQQ072) （Xjky2022089、2022YQQ072）
