湖南中医杂志2025，Vol.41Issue(10)：23-27,5.DOI:10.16808/j.cnki.issn1003-7705.2025.10.005
参芪扶正注射液辅助化疗方案对胃癌患者血清sICAM-1、CK18、MMP-9水平的影响
Effect of Shenqi Fuzheng injection as adjuvant therapy for chemoradiotherapy regimen on the serum levels of soluble intercellular adhesion molecule-1,cytokeratin-18,and matrix metallopeptidase-9 in patients with gastric cancer
摘要
Abstract
Objective:To investigate the effect of Shenqi Fuzheng injection as adjuvant therapy for chemo-radiotherapy regimen on the serum levels of soluble intercellular adhesion molecule-1(sICAM-1),cytokeratin 18(CK18),and matrix metallopeptidase-9(MMP-9)in patients with gastric cancer.Methods:A total of 88 patients with gastric cancer were enrolled and divided into treatment group and control group using the sealed envelope method,with 44 patients in each group.The patients in the control group received FOLFOX6 chemoradiotherapy regimen,while those in the treatment group received Shenqi Fuzheng injection in addition to the treatment in the control group,and the course of treatment was 18 weeks for both groups.The two groups were compared in terms of the serum levels of sICAM-1,CK18,and MMP-9,immune function(CD3+,CD4+,CD8+,and CD4+/CD8+),and toxic and side effects,and clinical outcome was assessed for both groups.Results:There was a significant difference in overall response rate between the treatment group and the control group[75.00％(33/44)vs 52.27％(23/44),P＜0.05].After treatment,both groups had significant changes in the serum levels of sICAM-1,CK18,and MMP-9 and the levels of CD3+,CD4+,CD8+,and CD4+/CD8+,and there were significant differences in these indicators between the two groups after treatment(P＜0.05).There was no significant difference in the incidence rate of toxic and side effects between the treatment group and the control group[11.36％(5/44)vs 15.91％(7/44),P＞0.05].Conclusion:Shenqi Fuzheng injection as adjuvant therapy for chemoradiotherapy regimen can significantly improve the treatment outcome of patients with gastric cancer,negatively regulate the serum levels of sI-CAM-1,CK18,and MMP-9,and improve immune function,and therefore,it holds promise for clinical application.关键词
胃癌/参芪扶正注射液/化疗/可溶性细胞间黏附分子-1/细胞角蛋白18/基质金属蛋白酶-9Key words
gastric cancer/Shenqi Fuzheng injection/chemotherapy/soluble intercellular adhesion mole-cule-1/cytokeratin 18/matrix metallopeptidase-9分类
医药卫生引用本文复制引用
刘湘麟,张向阳..参芪扶正注射液辅助化疗方案对胃癌患者血清sICAM-1、CK18、MMP-9水平的影响[J].湖南中医杂志,2025,41(10):23-27,5.基金项目
国家中医药管理局"胃癌毒邪论治"重点研究室开放项目(202258) （202258）
