纺织高校基础科学学报2025，Vol.38Issue(5)：17-25,9.DOI:10.13338/j.issn.1006-8341.2025.05.003
pH响应性海藻酸钠/丝素蛋白复合水凝胶的制备及其释药性能
Preparation and drug release performance study of pH-responsive sodium alginate/silk fibroin composite hydrogel
摘要
Abstract
In order to prepare natural polymer hydrogels with pH-responsive drug release proper-ties,sodium alginate was oxidized with ammonium persulfate(APS)to obtain oxidized sodium al-ginate(OSA).OSA was then grafted with dopamine(DA)through an amidation reaction to pre-pare dopamine-grafted oxidized sodium alginate(OSA-DA).OSA-DA was cross-linked with silk fibroin(SF)and Fe3+was introduced to prepare a composite hydrogel with a double-network structure.The structure,water absorption performance,drug release performance,antioxidant properties and adhesion properties of the hydrogel were characterized and tested.The results show that the optimal preparation conditions for the hydrogel were nSA∶nAPS=1∶8 and reaction for 18 h,nOSA∶nDA of 1∶2 to prepare OSA-DA,and mOSA-DA∶mSF=1∶1.With the increase of silk fibroin content,the swelling rate of the hydrogel first increased and then decreased.When mOSA-DA∶mSF is 1∶1,the swelling rate of the hydrogel reached the maximum,which is 638.1％.The swelling rate and drug release performance of the hydrogel were significantly affected by the environmental pH.In an acidic environment,it rapidly swelled and decomposed,with a fast drug release rate.In an alkaline environment,it swelled stably with a slow drug release rate.It also ex-hibits excellent antioxidant properties and good adhesion.关键词
氧化海藻酸钠/多巴胺/丝素蛋白/水凝胶/释药性能/pH响应Key words
oxidized sodium alginate/dopamine/silk fibroin/hydrogel/drug release property/pH response分类
通用工业技术引用本文复制引用
林海涛,巢梦颖,徐亮,凌新龙..pH响应性海藻酸钠/丝素蛋白复合水凝胶的制备及其释药性能[J].纺织高校基础科学学报,2025,38(5):17-25,9.基金项目
广西科技大学博士基金项目(17Z07) （17Z07）
广西科技大学研究生教育创新计划项目(GKYC 202444) （GKYC 202444）
