分子影像学杂志2025，Vol.48Issue(10)：1198-1204,7.DOI:10.12122/j.issn.1674-4500.2025.10.02
动脉粥样硬化合并颅内动脉瘤患者的血流动力学特征及其与蛛网膜下腔出血风险的相关性
Hemodynamic features in atherosclerosis with intracranial aneurysms and its relationship with subarachnoid hemorrhage risk
摘要
Abstract
Objective Based on head and neck CT angiography imaging data,this study aimed to apply computational fluid dynamics technology to analyze the influence of atherosclerosis(AS)on the hemodynamics of intracranial aneurysms and explore its guiding value for clinical evaluation.Methods A retrospective analysis was conducted on the clinical data of 178 patients with intracranial aneurysms admitted to The Second Affiliated Hospital of Bengbu Medical University from June 2023 to January 2025.Patients were divided into four groups based on the presence of AS and the occurrence of subarachnoid hemorrhage(SAH):intracranial aneurysm(IA)group,AS+IA group,SAH group,and AS+SAH group.All patients underwent head and neck CT angiography examinations.Three-dimensional vascular models were reconstructed,and computational fluid dynamics simulations were performed to calculate hemodynamic parameters including wall shear stress(WSS),time-averaged wall shear stress(TAWSS),oscillatory shear index(OSI),relative residence time,and blood flow velocity.Hemodynamic differences between AS-complicated aneurysms and simple aneurysms were compared,and their correlation with SAH was analyzed.Results No significant difference in aneurysm size was observed between groups(P>0.05).The aspect ratio(AR)and size ratio(SR)were significantly higher in the AS group than in the non-AS group(P<0.05),and SAH patients also showed significantly higher AR and SR values than non-SAH patients(P<0.05).Hemodynamic analysis revealed significantly increased blood flow velocity and OSI values,along with decreased TAWSS and normalized WSS in the AS group(P<0.05).Similar hemodynamic alterations were observed in SAH patients.Conclusion Through numerical simulation and imaging analysis,AS significantly altered the hemodynamic characteristics of intracranial aneurysms,manifested as increased blood flow velocity,elevated OSI,and reduced WSS.These changes were closely associated with an increased risk of aneurysm rupture.Computational fluid dynamics technology can provide important reference for clinical evaluation of aneurysm stability and SAH risk prediction.关键词
动脉粥样硬化/颅内动脉瘤/血流动力学/蛛网膜下出血Key words
atherosclerosis/intracranial aneurysm/hemodynamics/subarachnoid hemorrhage引用本文复制引用
姬若诗,闫春春,刘三春,邹璇,姚佳,徐加利..动脉粥样硬化合并颅内动脉瘤患者的血流动力学特征及其与蛛网膜下腔出血风险的相关性[J].分子影像学杂志,2025,48(10):1198-1204,7.基金项目
数字医学与智慧健康安徽省重点实验室(蚌埠医科大学)开放课题(AHCM2024W011) （蚌埠医科大学）
安徽省重点实验室开放课题(AHCM2023W001) （AHCM2023W001）
蚌埠医学院自然科学重点项目(2022byzd076) （2022byzd076）
