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Osteoclast-independent osteocyte dendrite defects in mice bearing the osteogenesis imperfecta-causing Sp7 R342C mutation

Jialiang S.Wang Cristal S.Yee Tamara N.Alliston Marc N.Wein Katelyn Strauss Caroline Houghton Numa Islam Sung-Hee Yoon Tatsuya Kobayashi Daniel J.Brooks Mary L.Bouxsein Yingshe Zhao

骨研究（英文版）2025，Vol.13Issue(5)：1211-1223,13.

骨研究（英文版）2025，Vol.13Issue(5)：1211-1223,13.DOI:10.1038/s41413-025-00440-1

Osteoclast-independent osteocyte dendrite defects in mice bearing the osteogenesis imperfecta-causing Sp7 R342C mutation

Jialiang S.Wang ¹Cristal S.Yee ²Tamara N.Alliston ²Marc N.Wein ³Katelyn Strauss ⁴Caroline Houghton ⁴Numa Islam ⁵Sung-Hee Yoon ⁴Tatsuya Kobayashi ⁴Daniel J.Brooks ⁶Mary L.Bouxsein ⁶Yingshe Zhao⁴

作者信息

1. Charles and Jane Pak Center for Mineral Metabolism and Clinical Research,University of Texas Southwestern Medical Center,Dallas,TX,USA||Department of Physiology,University of Texas Southwestern Medical Center,Dallas,TX,USA||Department of Internal Medicine,University of Texas Southwestern Medical Center,Dallas,TX,USA||Endocrine Unit,Massachusetts General Hospital,Harvard Medical School,Boston,MA,USA
2. Department of Orthopaedic Surgery,University of California in San Francisco,San Francisco,CA,USA
3. Endocrine Unit,Massachusetts General Hospital,Harvard Medical School,Boston,MA,USA||Broad Institute of Harvard and MIT,Cambridge,MA,USA||Harvard Stem Cell Institute,Cambridge,MA,USA
4. Endocrine Unit,Massachusetts General Hospital,Harvard Medical School,Boston,MA,USA
5. Charles and Jane Pak Center for Mineral Metabolism and Clinical Research,University of Texas Southwestern Medical Center,Dallas,TX,USA
6. Endocrine Unit,Massachusetts General Hospital,Harvard Medical School,Boston,MA,USA||Department of Orthopedic Surgery,Center for Advanced Orthopedic Studies,Beth Israel Deaconess Medical Center,Harvard Medical School,Boston,MA,USA
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摘要

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Jialiang S.Wang,Cristal S.Yee,Tamara N.Alliston,Marc N.Wein,Katelyn Strauss,Caroline Houghton,Numa Islam,Sung-Hee Yoon,Tatsuya Kobayashi,Daniel J.Brooks,Mary L.Bouxsein,Yingshe Zhao..Osteoclast-independent osteocyte dendrite defects in mice bearing the osteogenesis imperfecta-causing Sp7 R342C mutation[J].骨研究（英文版）,2025,13(5):1211-1223,13.

基金项目

We thank all members of the UT Southwestern Charles and Jane Pak Center for Mineral Metabolism and Clinical Research,and the Massachusetts General Hospital Endocrine Unit for helpful discussions.J.S.W.acknowledges funding support from the National Institute of Health(K99AR081897,R00AR081897).M.N.W.acknowledges funding support from the National Institute of Health(P01DK011794,R01DK116716),the Smith Family Foundation Odyssey Award,and the Chen Institute Massachusetts General Hospital Research Scholar(2024-2029)award.μCT and bone histomorpho-metry were performed by the Center for Skeletal Research at Massachusetts General Hospital,a NIH-funded program(P30AR066261 and AR075042)led by Mary Bouxsein and Marie Demay). （K99AR081897,R00AR081897）

骨研究（英文版）

ISSN：2095-4700

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