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The mitochondrial E3 ligase MAPL SUMOylates Drp1 to facilitate mitochondrial fission in intervertebral disc degeneration

Zhidi Lin Zuochong Yu Xiaosheng Ma Fei Zou Xiao Lu Guangyu Xu Jian Song Hongli Wang Xinlei Xia Feizhou Lu Jianyuan Jiang Wei Zhu

骨研究（英文版）2025，Vol.13Issue(5)：1239-1251,13.

骨研究（英文版）2025，Vol.13Issue(5)：1239-1251,13.DOI:10.1038/s41413-025-00449-6

The mitochondrial E3 ligase MAPL SUMOylates Drp1 to facilitate mitochondrial fission in intervertebral disc degeneration

Zhidi Lin ¹Zuochong Yu ²Xiaosheng Ma ¹Fei Zou ¹Xiao Lu ¹Guangyu Xu ¹Jian Song ¹Hongli Wang ¹Xinlei Xia ¹Feizhou Lu ¹Jianyuan Jiang ¹Wei Zhu¹

作者信息

1. Department of Orthopedics,Huashan Hospital,Fudan University,Shanghai,China
2. Department of Orthopedics,Jinshan Hospital,Fudan University,Shanghai,China
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摘要

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Zhidi Lin,Zuochong Yu,Xiaosheng Ma,Fei Zou,Xiao Lu,Guangyu Xu,Jian Song,Hongli Wang,Xinlei Xia,Feizhou Lu,Jianyuan Jiang,Wei Zhu..The mitochondrial E3 ligase MAPL SUMOylates Drp1 to facilitate mitochondrial fission in intervertebral disc degeneration[J].骨研究（英文版）,2025,13(5):1239-1251,13.

基金项目

This work was supported by National Natural Science Foundation of China(82272549,82472505,and 82472498) （82272549,82472505,and 82472498）

National key Research and Development plan,Ministry of Science and Technology of the People's Republic of China(2022YFC2407203) （2022YFC2407203）

the Young Health Talents of Shanghai Municipal Health Commission,China(2022YQ011) （2022YQ011）

China Medical Education Association(3030537245) （3030537245）

The Youth Talent Project of Huashan Hospital(30302164006). （30302164006）

骨研究（英文版）

ISSN：2095-4700

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