骨研究(英文版)2025,Vol.13Issue(5):1282-1294,13.DOI:10.1038/s41413-025-00452-x
Osteocytic vinculin controls bone mass by modulating Mef2c-driven sclerostin expression in mice
Osteocytic vinculin controls bone mass by modulating Mef2c-driven sclerostin expression in mice
Yishu Wang 1Guozhi Xiao 1Jianmei Huang 2Sixiong Lin 3Lei Qin 4Dingyu Hao 1Peijun Zhang 1Shaochuan Huo 5Xuenong Zou 6Di Chen7
作者信息
- 1. Department of Biochemistry,Homeostatic Medicine Institute School of Medicine Shenzhen Key Laboratory of Cell Microenvironment,Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research,Southern University of Science and Technology,Shenzhen,China
- 2. Department of Biochemistry,Homeostatic Medicine Institute School of Medicine Shenzhen Key Laboratory of Cell Microenvironment,Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research,Southern University of Science and Technology,Shenzhen,China||The First Affiliated Hospital,Southern University of Science and Technology,Shenzhen,China
- 3. Department of Biochemistry,Homeostatic Medicine Institute School of Medicine Shenzhen Key Laboratory of Cell Microenvironment,Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research,Southern University of Science and Technology,Shenzhen,China||Department of Spine Surgery,Orthopedic Research Institute,The First Affiliated Hospital of Sun Yat-sen University,Guangdong Provincial Key Laboratory of Orthopedics and Traumatology,Guangzhou,China||Department of Orthopaedics,The First Affiliated Hospital of Guangzhou Medical University,Guangzhou,China
- 4. Department of Orthopedics,Shenzhen Nanshan People's Hospital,and the 6th Affiliated Hospital of Shenzhen University Medical School,Shenzhen,China
- 5. Department of Biochemistry,Homeostatic Medicine Institute School of Medicine Shenzhen Key Laboratory of Cell Microenvironment,Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research,Southern University of Science and Technology,Shenzhen,China||Research Institute,Shenzhen Hospital(Futian)of Guangzhou University of Chinese Medicine,Shenzhen,China
- 6. Department of Spine Surgery,Orthopedic Research Institute,The First Affiliated Hospital of Sun Yat-sen University,Guangdong Provincial Key Laboratory of Orthopedics and Traumatology,Guangzhou,China
- 7. Research Center for Human Tissues and Organs Degeneration,Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences,Shenzhen,China
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Yishu Wang,Guozhi Xiao,Jianmei Huang,Sixiong Lin,Lei Qin,Dingyu Hao,Peijun Zhang,Shaochuan Huo,Xuenong Zou,Di Chen..Osteocytic vinculin controls bone mass by modulating Mef2c-driven sclerostin expression in mice[J].骨研究(英文版),2025,13(5):1282-1294,13.基金项目
The authors acknowledge the assistance of Core Research Facilities of Southern University of Science and Technology.This work was supported,in part,the Shenzhen Medical Research Funds(B2402033),the Shenzhen Fundamental Research Program(JCYJ20220818100617036),the National Natural Science Foundation of China Grants(82250710175,82261160395,82430078,82230081),the Guangdong Provincial Science and Technology Innovation Council Grant(2017B030301018),the National Key Research and Development Program of China Grant(2019YFA0906004),and the China Postdoctoral Science Foundation(2021M691435). (B2402033)