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Chemotherapeutic drug-triggered AEP-cleaved G3BP1 orchestrates stress granules/nucleoli/mitochondria in osteosarcoma

Zhonggang Shi Jianwei Ge Yongming Qiu Juxiang Chen Jiayi Chen Chunhui Ma Yingying Lin Jianyi Zhao Qi Lv Keman Liao Lu Cao Jian Yang Mengying Wang Li Zhou Haoping Xu

骨研究（英文版）2025，Vol.13Issue(5)：1295-1307,13.

骨研究（英文版）2025，Vol.13Issue(5)：1295-1307,13.DOI:10.1038/s41413-025-00453-w

Chemotherapeutic drug-triggered AEP-cleaved G3BP1 orchestrates stress granules/nucleoli/mitochondria in osteosarcoma

Zhonggang Shi ¹Jianwei Ge ²Yongming Qiu ³Juxiang Chen ⁴Jiayi Chen ¹Chunhui Ma ⁵Yingying Lin ¹Jianyi Zhao ¹Qi Lv ⁶Keman Liao ¹Lu Cao ¹Jian Yang ²Mengying Wang ³Li Zhou ⁷Haoping Xu¹

作者信息

1. Department of Radiation Oncology,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai,China||Shanghai Key Laboratory of Proton-Therapy,Shanghai,China
2. Department of Neurosurgery,Ren Ji Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai,China
3. Brain Injury Center,Shanghai Institute of Head Trauma,Ren Ji Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai,China
4. Department of Neurosurgery,Shanghai Changhai Hospital,Naval Medical University,Shanghai,China
5. Department of Orthopedic Surgery,Shanghai Geriatric Medical Center,Shanghai,China
6. Department of Medical Imaging,Tongji Hospital,Tongji University School of Medicine,Shanghai,China
7. Department of Radiation Oncology,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai,China||Shanghai Key Laboratory of Proton-Therapy,Shanghai,China||Brain Injury Center,Shanghai Institute of Head Trauma,Ren Ji Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai,China
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摘要

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Zhonggang Shi,Jianwei Ge,Yongming Qiu,Juxiang Chen,Jiayi Chen,Chunhui Ma,Yingying Lin,Jianyi Zhao,Qi Lv,Keman Liao,Lu Cao,Jian Yang,Mengying Wang,Li Zhou,Haoping Xu..Chemotherapeutic drug-triggered AEP-cleaved G3BP1 orchestrates stress granules/nucleoli/mitochondria in osteosarcoma[J].骨研究（英文版）,2025,13(5):1295-1307,13.

基金项目

This work was supported by the National Key R&D Program of China(grant number 2023ZD0502206,2024YFB3213200,Topic No.2024YFB3213204),National Natural Science Foundation of China(nos.82273278,82373514,82373202,82272728,82002630,81772654),the National Key Research and Development Program of China(grant number 2022YFC2404602),Shanghai Hospital Development Center Founda-tion(grant number SHDC12023108),Scientific and Technological Innovation Action Plan of Shanghai Science and Technology Committee(grant number 22Y31900103),Beijing Science and Technology Innovation Medical Development Foundation(grant number KC2021-JX-0170-9),the Shanghai Association for Science and Technology(nos.201409003000,201409002400,20YF1426200),Shanghai Science and Technol-ogy Innovation Action Plan(grant number 23Y41900100). （grant number 2023ZD0502206,2024YFB3213200,Topic No.2024YFB3213204）

骨研究（英文版）

ISSN：2095-4700

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