神经损伤与功能重建2025，Vol.20Issue(11)：651-654,678,5.DOI:10.16780/j.cnki.sjssgncj.20251209
伤害性感觉神经元—肿瘤轴:从神经肽到肿瘤神经支配
The Nociceptor-tumor Axis:from Neuropeptides to Tumor Innervation
司绍梦 1辛悦阳 1徐卉1
作者信息
- 1. 华中科技大学同济医学院附属同济医院麻醉学与疼痛医学科,老年麻醉与围术期脑健康湖北省重点实验室,武汉市老年麻醉临床医学研究中心 武汉 430030
- 折叠
摘要
Abstract
As the principal afferent pathway for noxious stimuli,nociceptive sensory neurons have been shown to actively participate in tumor progression.Numerous studies indicate a complex bidirectional crosstalk between sensory neurons and tumors:tumors promote tumor innervation by releasing neurotrophic factors and axon guidance molecules,while sensory neurons remodel the tumor microenvironment by releasing neuropeptides,thereby modulating cancer proliferation,angiogenesis,immune evasion,and metastasis.However,this sensory neuro-tumor interaction exhibits marked heterogeneity across tumors of different organ origins,and its organ-specific mechanisms have yet to be systematically elucidated.Accordingly,this review aims to systematically delineate the organ-specific mechanisms by which nociceptive sensory neurons contribute to the initiation and progression of multiple solid tumors,evaluate the therapeutic potential of targeting the sensory neuron-tumor signaling axis,and provide a theoretical basis and research directions for developing organ-specific neuromodulatory strategies.关键词
伤害性感觉神经元/癌症神经科学/肿瘤微环境Key words
nociceptive sensory neurons/cancer neuroscience/tumor microenvironment分类
临床医学引用本文复制引用
司绍梦,辛悦阳,徐卉..伤害性感觉神经元—肿瘤轴:从神经肽到肿瘤神经支配[J].神经损伤与功能重建,2025,20(11):651-654,678,5.
