广西医学2025，Vol.47Issue(10)：1391-1395,5.DOI:10.11675/j.issn.0253-4304.2025.10.02
2型糖尿病患者CD36-rs1722505基因多态性分布特征及其与冠状动脉粥样硬化的相关性研究
Study on CD36-rs1722505 gene polymorphism distribution characteristics and its correlation with coronary atherosclerosis in patients with type 2 diabetes mellitus
摘要
Abstract
Objective To investigate the distribution characteristics of CD36-rs1722505 gene polymorphism in patients with type 2 diabetes mellitus and its correlation with coronary atherosclerosis.Methods A total of 71 patients receiving coronary angiography examination were selected,and they were assigned to type 2 diabetes mellitus group(17 cases)or control group(54 cases)according to the presence of concomitant type 2 diabetes mellitus.The general data and blood biochemical indices of both groups were collected.Genotype of CD36-rs1722505 in patients of both groups was detected.Severity of coronary atherosclerosis was also compared between the two groups.Results The type 2 diabetes mellitus group exhibited higher proportion of hypertension history and systolic blood pressure as compared with the control group(P<0.05).In the type 2 diabetes mellitus group,the proportions of genotype TT,TC and CC of CD36-rs1722505 gene were 0,58.8%,and 41.2%,whereas in the control group,the proportions being 13.0%,51.8%,and 35.2%,respectively.There was no statistically significant difference in various genotype and allele frequency of CD36-rs1722505 gene between patients in the two groups(P>0.05).The proportions of double-vessel disease and triple-vessel disease of patients in the type 2 diabetes mellitus group were higher than those in the control group(P<0.05).Conclusion Severity of coronary atherosclerosis in patients with type 2 diabetes mellitus is relatively high.However,CD36-rs1722505 gene polymorphism loci may not the key factors for affecting coronary atherosclerosis in patients with type 2 diabetes mellitus.关键词
2型糖尿病/冠状动脉粥样硬化/CD36/单核苷酸多态性/相关性Key words
Type 2 diabetes mellitus/Coronary atherosclerosis/CD36/Single nucleotide polymorphism/Correlation分类
医药卫生引用本文复制引用
黄羡,周雪梅,谭艳粒,黄济华,张薇,余博先,张峥嵘,庞翠军..2型糖尿病患者CD36-rs1722505基因多态性分布特征及其与冠状动脉粥样硬化的相关性研究[J].广西医学,2025,47(10):1391-1395,5.基金项目
广西医疗卫生适宜技术开发与推广应用项目(S2018041) （S2018041）
广西壮族自治区卫生健康委员会自筹经费科研课题(Z-A20230682) （Z-A20230682）
