广西医学2025，Vol.47Issue(10)：1408-1418,11.DOI:10.11675/j.issn.0253-4304.2025.10.05
多元规范化管理体系在改善T2DM患者糖脂代谢水平中的应用效果
Application effect of a diversified standardized management system in the improvement of glucose and lipid metabolism levels in T2DM patients
摘要
Abstract
Objective To evaluate the application effect of a diversified standardized management system in the improvement of glucose and lipid metabolism levels in patients with type 2 diabetes mellitus(T2DM).Methods A total of 668 T2DM patients were selected as the research subjects.All patients received professional healthy management intervention based on routine intervention after discharge.Glucose and lipid metabolism indicator levels,including HbA1c,fasting blood glucose(FBG),2-hour postprandial blood glucose(2hPBG),total cholesterol(TC),triglyceride(TG),HDL-C,LDL-C were compared between patients before intervention(T0),and 1-<3 months(T1),3-<6 months(T2),6-<12 months(T3),12-<18 months(T4),≥18 months(T5)after intervention.Glucose and lipid metabolism indicator levels were compared between patients with different genders and ages before and after intervention,and change in glucose and lipid metabolism indicators(∆)was compared between patients with different ages,genders and intervention frequencies.Results(1)Generally,HbA1c,2hPBG,TC,and LDL-C levels of T2DM patients were lower at time points T1-T5 than at time point T0,TG level was lower at time points T1-T2 than at time point T0,whereas HDL-C level was higher at time ponts T1-T4 than at time point T0(P<0.05).(2)Whether male or female patients,the levels of HbA1c,2hPBG,TC,TG and LDL-C at most of the time points after intervention were lower than those at T0,while HDL-C level was higher than that at T0(P<0.05).∆HbA1c at T1,T2,T4 and T5,as well as ∆2hPBG at T1 of male patients were greater than those of female patients(P<0.05).(3)Among patients aged≤60 years,the levels of HbA1c,2hPBG,TC,TG and LDL-C at most of the time points were lower than those at T0,whereas HDL-C level was higher than that at T0(P<0.05).Among patients aged>60 years,the levels of HbA1c,2hPBG and LDL-C at the most of the time points were lower than those at T0,while FBG and HDL-C levels were higher than those at T0(P<0.05).∆HbA1c at T1-T3,and T5,as well as ∆TG and∆LDL-C at T2 of patients aged≤60 years were all greater than those of patients aged>60 years(P<0.05).(4)The low-frequency intervention group yielded greater ∆HbA1c(both group>0),∆TG(the low-frequency intervention group>0 while the high-frequency intervention group<0)at T5,as well as ∆FBG(both group<0)at T4 as compared with the high-frequency intervention group(P<0.05).Conclusion The diversified standardized management system can effectively ameliorate glucose and lipid metabolism levels of T2DM patients,exerting favorable promotion values.Patients of different genders,ages,and intervention frequencies can all benefit to varying degrees from this management system,but male patients,those aged≤60 years,and those with a lower-frequency intervention may benefit more.关键词
2型糖尿病/多元规范化管理/糖脂代谢/干预效果Key words
Type 2 diabetes mellitus/Diversified standardized management/Glucose and lipid metabolism/Intervention effect分类
医药卫生引用本文复制引用
谭艳粒,谢红宁,韦咏,张峥嵘,庞翠军..多元规范化管理体系在改善T2DM患者糖脂代谢水平中的应用效果[J].广西医学,2025,47(10):1408-1418,11.基金项目
广西医疗卫生适宜技术开发与推广应用项目(S2018041) （S2018041）
广西壮族自治区卫生健康委员会自筹经费科研课题(Z-A20230682、Z20191064) （Z-A20230682、Z20191064）
