解放军医学杂志2025，Vol.50Issue(10)：1338-1346,9.DOI:10.11855/j.issn.0577-7402.1805.2025.0422
外周免疫细胞在阿尔茨海默病中的作用及机制研究进展:聚焦肠道菌群
Research progress on the roles and mechanisms of peripheral immune cells in Alzheimer's disease:focus on the gut microbiota
陈雅婷 1陈清诚 1胡利 2刘洲1
作者信息
- 1. 广东医科大学附属医院神经内科,广东 湛江 524001||广东医科大学附属医院神经病学研究所,广东 湛江 524001||广东省衰老相关心脑疾病重点实验室,广东 湛江 524001
- 2. 广东医科大学附属医院神经病学研究所,广东 湛江 524001||广东医科大学组织学与胚胎学教研室,广东 湛江 524023
- 折叠
摘要
Abstract
Alzheimer's disease(AD)is a common neurodegenerative disease in the elderly.Increasing evidence shows that peripheral immune cells are involved in the occurrence and development of AD.Both gut microbiota dysbiosis and abnormalities of peripheral immune cells occur in the early stage of AD.The gut microbiota can influence the central nervous system through mechanisms such as the gut-brain axis and the regulatory effects on peripheral immune cells.AD treatment methods targeting the gut microbiota and immune cells have been receiving increasing attention.This review summarizes the regulatory effects and mechanisms of the gut microbiota on peripheral immune cells,as well as the research progress on the gut microbiota's roles in the occurrence and development of AD,aiming to provide new ideas for relevant research on the prevention,diagnosis,and treatment of AD.关键词
阿尔茨海默病/免疫细胞/肠道菌群/血脑屏障Key words
Alzheimer's disease/immune cells/gut microbiota/blood-brain barrier分类
临床医学引用本文复制引用
陈雅婷,陈清诚,胡利,刘洲..外周免疫细胞在阿尔茨海默病中的作用及机制研究进展:聚焦肠道菌群[J].解放军医学杂志,2025,50(10):1338-1346,9.
