解放军医学杂志2025，Vol.50Issue(10)：1284-1289,6.DOI:10.11855/j.issn.0577-7402.0125.2025.0609
儿童睡眠相关肺泡低通气障碍临床特征、多导睡眠监测特征及无创正压通气的治疗效果
Clinical characteristics,polysomnographic features,and efficacy of non-invasive positive pressure ventilation in children with sleep related hypoventilation disorder
摘要
Abstract
Objective To analyze the clinical characteristics and polysomnographic(PSG)features of children with sleep-related hypoventilation disorder(SRHD),facilitate its auxiliary diagnosis,and explore the therapeutic effects of non-invasive positive pressure ventilation(NPPV)on SRHD children.Methods A retrospective study was conducted on the medical records of 16 children diagnosed with SRHD who were admitted and treated in the Department of Respiratory Diseases,Children's Hospital Affiliated to Capital Institute of Pediatrics,from July 2016 to June 2024.Additionally,69 children with severe obstructive sleep apnea(OSA)who visited the Department of Respiratory Diseases and Otolaryngology at the same hospital from July 2021 to June 2022 and met the inclusion criteria were enrolled to compare clinical and PSG characteristics between SRHD and OSA children.The therapeutic effects of NPPV were evaluated.Results(1)Among 16 SRHD children,4(25.0%)presented with cyanosis,9(56.3%)with dyspnea,and 5(31.3%)with convulsions.(2)Eleven SRHD children completed PSG+PetCO2,showing PSG characteristics consistent with severe OSA.(3)Compared with severe OSA children,SRHD children had lower proportion of rapid eye movement(REM)sleep,mean and minimum oxygen saturation,and higher obstructive hypopnea index,obstructive apnea-hypopnea index(OAHI),and apnea-hypopnea index(AHI)(P<0.05).(4)When compared with 25 severe OSA children with OAHI>25,the ratio of obstructive apnea to hypoventilation was approximately 1:30 in SRHD children,with more significant decrease in pulse oxygen saturation(P<0.05).(5)After NPPV treatment for 12 SRHD children,clinical symptoms and PSG indicators significantly improved(P<0.05).Conclusions The 3 main symptoms in SRHD children are dyspnea,convulsions,and cyanosis.For children with unexplained cyanosis and PSG meeting severe OSA criteria,especially those with predominantly obstructive hypoventilation events and significant SpO2 reduction,PetCO2 monitoring should be performed to detect SRHD early.NPPV improves clinical symptoms,reduces sleep-related events,increases sleep-time SpO2,and enhances sleep safety in SRHD children.关键词
睡眠相关肺泡低通气障碍/临床特征/多导睡眠监测/无创正压通气Key words
sleep related hypoventilation disorder/clinical characteristics/polysomnography/non-invasive positive pressure ventilation分类
医药卫生引用本文复制引用
陶涛,黄贵民,常丽..儿童睡眠相关肺泡低通气障碍临床特征、多导睡眠监测特征及无创正压通气的治疗效果[J].解放军医学杂志,2025,50(10):1284-1289,6.基金项目
This work was supported by the Capital's Funds for Health Improvement and Research(CFH2024-2G-1135)首都卫生发展科研专项(CFH2024-2G-1135) （CFH2024-2G-1135）
