军事医学2025，Vol.49Issue(10)：747-753,7.DOI:10.7644/j.issn.1674-9960.2025.10.004
小补心汤总黄酮对小鼠前额叶皮质局部场电位的作用
Effects of total flavonoid extracted from Xiaobuxin-Tang on local field potentials of the frontal cortexin mice
摘要
Abstract
Objective To investigate the pharmacological mechanism through which total flavonoids extracted from Xiaobuxin-Tang(XBXT-2)affects neural network activities in the frontal cortex by focusing on the effects of XBXT-2 on the cortical field potentials in the frontal association cortex(FrA)in mice.Methods Cortical electrodes were implanted into the skull of C57BL/6J mice targeting the FrA.After a 7-day recovery period,the mice were administered XBXT-2 intragastrically at a dose of 100 mg/kg,and 1 hour later,local field potential(LFP)in the FrA were recorded for 30 minutes.Spectral analysis of the data was performed using Neuro Explorer software.Changes in the power spectral density of α,β,θ,γ,and δ frequency bands before and after drug administration were analyzed using GraphPad Prism 10.3.Phase-amplitude coupling of θ and γ oscillations was analyzed using Matlab 2021 software.Results It was found that the oral administration of XBXT-2 significantly suppressed high-frequency γ oscillations while simultaneously enhancing θ,β,α,and δ oscillations in FrA of mice compared to the control.Furthermore,XBXT-2 treatment markedly strengthened the phase-amplitude coupling between θ and γ oscillations.Conclusion XBXT-2 possibly affects emotional and cognitive functions by modulating neural network activity in FrA and enhancing θ-γ phase-amplitude coupling in mice.关键词
小补心汤总黄酮/局部场电位/θ振荡/γ振荡/皮质脑电Key words
XBXT-2/local field potential/θ oscillations/γ oscillations/cortical electrodes分类
药学引用本文复制引用
杨进,范琼尹,张有志,刘爽,李劲草,张树卓,王彦凯,邱仁洪,顾永芳,薛瑞,李硕,张杨..小补心汤总黄酮对小鼠前额叶皮质局部场电位的作用[J].军事医学,2025,49(10):747-753,7.基金项目
北京市自然科学基金项目(7254511) （7254511）
国家中医药管理局高水平中医药重点学科建设项目(zyyzdxk-2023311) （zyyzdxk-2023311）
