临床传统医学和药理学（英文）2025，Vol.6Issue(3)：40-52,13.DOI:10.1016/j.ctmp.2025.200233
浆果乌桕(Balakata baccata)花的治疗潜力:甲醇提取物的化学表征、生物活性及计算预测分析
Unlocking the therapeutic potential of Balakata baccata flowers:chemical profiling,biological activities,and computational insights of its methanolic extracts
Nusrat Jahan Rittika 1Rakibur Rahman 1Ferdousi Akter 2Sadab Sipar Ibban 1Sadia Bintea Yeasin 1Areez Hafiz Md.Zahid3
作者信息
- 1. Department of Pharmacy,Faculty of Science and Engineering,International Islamic University Chittagong,Chattogram 4318,Bangladesh
- 2. Department of Pharmacy,Faculty of Science and Engineering,International Islamic University Chittagong,Chattogram 4318,Bangladesh||Department of Pharmacy,Jahangirnagar University,Savar,Dhaka 1342,Bangladesh
- 3. Department of Computer and Communication Engineering,Faculty of Science and Engineering,International Islamic University Chittagong,Chattogram 4318,Bangladesh
- 折叠
摘要
Abstract
Background:The detrimental consequences of synthetic pharmaceuticals have generated interest in natural reme-dies.Balakata baccata(Roxb.)Esser a plant of ethnomedicinal significance,has been conventionally utilized for its anti-inflammatory and analgesic characteristics;nevertheless,its flowers are yet to be thoroughly investigated.
Objective:The current study examines the pharmacological potential of the methanol extract of B.baccata flowers(MEBBF)for antinociceptive,antipyretic,and anthelmintic effects.
Methods:MEBBF was assessed utilizing in vivo models,consisting of the acetic acid-induced writhing test,formalin-induced paw-licking test,yeast-induced pyrexia model,and Tubifex tubifex assay.GC-MS analysis was used to affirm the presence of bioactive chemicals,whereas molecular docking and ADMET analysis elucidated their mechanisms and safety profiles.
Results:The MEBBF demonstrated analgesic,antipyretic,and anthelmintic actions.It noticeably diminished pain responses,decreased temperature,and caused paralysis and mortality in Tubifex tubifex.Phytochemical analysis found flavonoids,phenolic compounds,and glycosides as principal bioactive constituents.Molecular docking of compounds from GC-MS of MEBBF demonstrated robust binding affinities with target proteins,while ADMET analysis suggested beneficial pharmacokinetic characteristics.
Conclusion:MEBBF has a high therapeutic potential for treating pain,fever,and helminthic diseases.Nevertheless,further research has to be done to substantiate these findings and confirm its curative applications.关键词
浆果乌桕/镇痛/解热/驱虫/分子对接/气相色谱-质谱联用/ADMET分析Key words
Balakata baccata/Antinociceptive/Antipyretic/Anthelmintic/Molecular docking/GC-MS/ADMET analysis引用本文复制引用
Nusrat Jahan Rittika,Rakibur Rahman,Ferdousi Akter,Sadab Sipar Ibban,Sadia Bintea Yeasin,Areez Hafiz Md.Zahid..浆果乌桕(Balakata baccata)花的治疗潜力:甲醇提取物的化学表征、生物活性及计算预测分析[J].临床传统医学和药理学（英文）,2025,6(3):40-52,13.
