上海预防医学2025，Vol.37Issue(9)：725-730,736,7.DOI:10.19428/j.cnki.sjpm.2025.24638
上海市50岁及以上社区人群带状疱疹后神经痛发病及影响因素
The incidence and influencing factors of postherpetic neuralgia in community-based populations aged 50 years and above in Shanghai
摘要
Abstract
[Objective]To analyze the incidence and influencing factors of postherpetic neuralgia(PHN)among herpes zoster(HZ)patients aged 50 years and above in the community-based population of Shanghai who had not received the recombinant zoster vaccine(RZV),so as to provide data support for formulating PHN prevention strategies.[Methods]Based on baseline survey data,physical examinations,biochemical indicator tests,annual clinical diagnosis and treatment data from the Shanghai Suburban Adult Cohort,as well as the RZV vaccination data from the vaccination information platform of the Center for Disease Control and Prevention,the cumulative incidence rate of PHN was calculated.Logistic regression analyses were used to analyze the influencing factors of PHN.[Results]A total of 48 261 participants were included in this study,with 2 406 newly diagnosed HZ cases,among whom 11 had received at least one dose of RZV.Among 2 395 unvaccinated HZ patients,262 new PHN cases were identified,with a cumulative incidence rate of 10.94%(95%CI:9.72%‒12.26%).Factors influencing PHN incidence included age 70‒79 years(OR=2.069,95%CI:1.427‒3.028),history of immunosuppresant utilization(OR=1.592,95%CI:1.227‒2.072),and history of stroke(OR=1.657,95%CI:1.015‒2.605).For male patients,the influencing factors for PHN were age 70‒79 years(OR=2.319,95%CI:1.195‒4.802)and history of chronic bronchitis(OR=1.935,95%CI:1.010‒3.517),whereas,for female patients,age 70‒79 years(OR=1.767,95%CI:1.107‒2.831),history of immunosuppresant use(OR=1.603,95%CI:1.151‒2.245),history of stroke(OR=1.906,95%CI:1.059‒3.277),and alcohol consumption(OR=3.698,95%CI:1.093‒12.517)were influencing factors for PHN.[Conclusion]Individuals with advanced age,history of immunosuppresant utilization,stroke,chronic bronchitis,and alcohol consumption are at high risk for PHN.These individuals should be prioritized for RZV vaccination to reduce the occurrence of PHN and improve their quality of life.关键词
带状疱疹/带状疱疹后神经痛/队列研究/影响因素/免疫低下/累积发病率Key words
herpes zoster/postherpetic neuralgia/cohort study/influencing factor/immune deficiency/cumulative incidence rate分类
医药卫生引用本文复制引用
蒋淼,朱祺,吴毅凌,姜永根,张涛,赵根明..上海市50岁及以上社区人群带状疱疹后神经痛发病及影响因素[J].上海预防医学,2025,37(9):725-730,736,7.基金项目
上海市加强公共卫生体系建设三年行动计划(2023-2025年)重点学科(GWVI-11.1-23) （2023-2025年）
复旦大学公共卫生学院—嘉定区疾病预防控制中心公共卫生高质量发展重点学科(GWGZLXK-2023-02) （GWGZLXK-2023-02）
2024年度上海市公共卫生研究专项青年项目(2024GKQ17) （2024GKQ17）
