上海预防医学2025，Vol.37Issue(9)：768-775,8.DOI:10.19428/j.cnki.sjpm.2025.250016
上海市某区颗粒物及臭氧与非酒精性脂肪性肝病患病的关联
Association of particulate matter and ozone with the prevalence of non-alcoholic fatty liver disease in a district of Shanghai
摘要
Abstract
[Objective]To investigate the association of particulate matter and ozone with the prevalence of non-alcoholic fatty liver disease(NAFLD)in a district of Shanghai,and to provide epidemiological evidence for the further identification of early health hazards of air pollution and for the prevention and control of NAFLD.[Methods]Based on Songjiang Sub-cohort of Shanghai Natural Population Cohort,a cross-sectional survey design was used to recruit participants from 2016 to 2017.Annual average exposure levels to air pollution from 2009 to 2017 were matched to the participant's residential address using a high-resolution and high-quality ambient air pollutants dataset in China.NAFLD was diagnosed according to the"Guidelines for the prevention and treatment of metabolism-associated(non-alcoholic)fatty liver disease"by the Chinese Medical Association.Multivariate logistic regression models were employed to analyze the association between air pollution and the prevalence of NAFLD,and stratified analyses were used to compare differences by age,gender,obesity,and lifestyle habits within subgroups.[Results]A total of 32 791 individuals were included in the study.The prevalence of NAFLD among community residents in suburban Shanghai was 38.88%.For every 1 μg·m-3 increase in PM1,PM2.5,PM10,or O3,the risk of NAFLD increased correspongdinglt,with the odds ratios(95%CI)of 1.071(1.043‒1.099),1.065(1.042‒1.089),1.041(1.027‒1.055),or 1.061(1.032‒1.091),respectively.There were differences in effects across different gender,age,and obesity status subgroups.[Conclusion]PM1,PM2.5,PM10,and O3 are positively associated with an increased risk of NAFLD.Stratified analyses reveal that individuals aged 65 years old or above exhibited greater susceptibility to PM1,PM2.5,and O3,whereas those aged less than 65 years old are more vulnerable to PM10.Males are more sensitive to PM1 and O3,and females are more susceptible to PM2.5 and PM10.The association between air pollutant exposure and NAFLD risk is more pronounced among obese participants compared to that in non-obese counterparts.关键词
非酒精性脂肪性肝病/空气污染/自然人群/颗粒物/臭氧Key words
non-alcoholic fatty liver disease/air pollution/general population/particulate matter/ozone分类
医药卫生引用本文复制引用
顾玉,韩昕育,张钰皎,陈怡舟,邹帮玉,张铁军..上海市某区颗粒物及臭氧与非酒精性脂肪性肝病患病的关联[J].上海预防医学,2025,37(9):768-775,8.基金项目
国家科技基础资源调查专项(2019FY101103) （2019FY101103）
