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Sea cucumber intestinal hydrolysates alleviate insulin resistance through regulating IRS1/PI3K/AKT signaling pathway mediated by glutamine metabolism in high-fat and high-sucrose diet-induced mice

Meng Wang Man Yao Hao Yue Yingying Tian Zifang Zhao Changhu Xue Tiantian Zhang Yuming Wang

食品科学与人类健康（英文）2025，Vol.14Issue(10)：3850-3861,12.
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食品科学与人类健康（英文）2025，Vol.14Issue(10)：3850-3861,12.DOI:10.26599/FSHW.2024.9250417

Sea cucumber intestinal hydrolysates alleviate insulin resistance through regulating IRS1/PI3K/AKT signaling pathway mediated by glutamine metabolism in high-fat and high-sucrose diet-induced mice

Sea cucumber intestinal hydrolysates alleviate insulin resistance through regulating IRS1/PI3K/AKT signaling pathway mediated by glutamine metabolism in high-fat and high-sucrose diet-induced mice

Meng Wang 1Man Yao 1Hao Yue 2Yingying Tian 1Zifang Zhao 3Changhu Xue 4Tiantian Zhang 1Yuming Wang4

作者信息

  • 1. SKL of Marine Food Processing&Safety Control,College of Food Science and Engineering,Ocean University of China,Qingdao 266404,China
  • 2. Institute of Food&Nutrition Science and Technology,Shandong Academy of Agricultural Sciences,Jinan 250100,China
  • 3. SKL of Marine Food Processing&Safety Control,College of Food Science and Engineering,Ocean University of China,Qingdao 266404,China||Hainan Huayan Collagen Technology Co.,Haikou 571000,China
  • 4. SKL of Marine Food Processing&Safety Control,College of Food Science and Engineering,Ocean University of China,Qingdao 266404,China||Sanya Institute of Oceanography,Ocean University of China,Sanya 572000,China
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摘要

关键词

Sea cucumber intestinal hydrolysates/Insulin resistance/Glucose metabolism/Glutamine/Histone acetylation

Key words

Sea cucumber intestinal hydrolysates/Insulin resistance/Glucose metabolism/Glutamine/Histone acetylation

引用本文复制引用

Meng Wang,Man Yao,Hao Yue,Yingying Tian,Zifang Zhao,Changhu Xue,Tiantian Zhang,Yuming Wang..Sea cucumber intestinal hydrolysates alleviate insulin resistance through regulating IRS1/PI3K/AKT signaling pathway mediated by glutamine metabolism in high-fat and high-sucrose diet-induced mice[J].食品科学与人类健康（英文）,2025,14(10):3850-3861,12.

基金项目

This study was supported by National Key Research and Development Program of China(2023YFF1103901),the Taishan Scholars Program(tstp20240812),China Postdoctoral Science Foundation(2024M763107)and Postdoctoral Fellowship Program of CPSF(GZC20241617)and Youth Innovation Team Program of Universities in Shandong Province(2023KJ040). （2023YFF1103901）

食品科学与人类健康（英文）

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