摘要
Abstract
Obesity has become a global health challenge.Although Western medicine is highly effective in weight loss,it carries risks such as gastrointestinal reactions,pancreatitis,and retinopathy.Traditional Chinese materia medica has the advantages of multi-target and minimal side effects.Experimental results show that the pathogenesis of obesity involves multiple pathways,including disruption of gut microbiota(elevated F/B ratio),chronic inflammation(increased inflam-matory cytokines such as TNF-α and IL-6),neuroendocrine disorders(mutations,deletions,and dysregulation within the GPCRs family),and abnormal fat metabolism(reduced UCP1 expression),among multiple pathways.Active com-ponents of Chinese materia medica(such as alkaloids,flavonoids,polysaccharides,glycosides,etc.)exert weight-reduc-ing effects through mechanisms including regulating gut microbiota,improving neuroregulation,promoting fat brown-ing,and inhibiting inflammatory responses.Studies show that Chinese materia medica of the types of diuretic and phlegm-resolving,heat-clearing and phlegm-transforming,spleen and kidney tonifying,and blood-activating and Qi-regulating,through syndrome differentiation and treatment,target different types of obesity,collectively regulating ap-petite,lipid metabolism,and energy expenditure through multiple pathways involving the intestine,neuroendocrine,and fat.Chinese materia medica and its active components provide a new strategy for the treatment of obesity through a multi-target regulation mechanism via the intestine,neuroendocrine,and fat.关键词
肥胖症/中药及有效成分/多靶点干预/研究进展Key words
Obesity/Chinese Materia Medica and Its Active Ingredients/Multi-Target Intervention/Research Progress分类
医药卫生
