新发传染病电子杂志2025，Vol.10Issue(5)：12-16,5.DOI:10.19871/j.cnki.xfcrbzz.2025.05.003
糖化血红蛋白水平对糖尿病合并肺结核患者耐药发生的影响:C反应蛋白水平的中介效应
The impact of glycated hemoglobin A1c levels on drug resistance development in diabetes mellitus-pulmonary tuberculosis patients:the mediating effect of C reactive protein levels
摘要
Abstract
Objective The objective of this study was to explore the mediating role of C reactive protein(CRP)levels in the relationship between glycated hemoglobin A1c(HbA1c)and the occurrence of drug-resistant pulmonary tuberculosis(DR-PTB)in patients with diabetes mellitus-pulmonary tuberculosis.Method A total of 352 patients diagnosed with Diabetes mellitus-pulmonary tuberculosis at Qingdao public health clinical center from 2022 to 2024 were included.To analyze the mediating effect of CRP levels in the relationship between HbA1c and DR-PTB occurrence,with validation performed using the bootstrap method.Result Among the patients,85 cases(24.1%)were identified with DR-PTB.HbA1c showed positive correlations with CRP levels(r=0.459,P＜0.01)and DR-PTB occurrence(r=0.359,P＜0.01).CRP levels were also positively correlated with DR-PTB occurrence(r=0.441,P＜0.01).Regression analysis indicated that both HbA1c control(β=0.81)and CRP levels(β=1.17)significantly influenced DR-PTB occurrence(P＜0.001).The total effect of HbA1c on DR-PTB occurrence was 1.30,with a direct effect of 0.81.The mediating effect of CRP levels was 0.49,accounting for 37.69%of the total effect.Conclusion HbA1c and CRP levels are associated with DR-PTB occurrence in patients with diabetes mellitus-pulmonary tuberculosis,and there is a partial mediating effect of CRP levels between HbA1c and the occurrence of drug-resistant tuberculosis.关键词
糖尿病合并肺结核/糖化血红蛋白/C反应蛋白/耐药肺结核/中介效应Key words
Diabetes mellitus-pulmonary tuberculosis/Glycated hemoglobin A1c/C reactive protein/Drug-resistant pulmonary tuberculosis/Mediating effect分类
临床医学引用本文复制引用
李汶珊,纪雪芹,林梅,戚艳,王文丽,王超艺,丁晓,李同霞..糖化血红蛋白水平对糖尿病合并肺结核患者耐药发生的影响:C反应蛋白水平的中介效应[J].新发传染病电子杂志,2025,10(5):12-16,5.基金项目
1.山东省重点研发计划(2021SFGC0504) （2021SFGC0504）
2.2024年青岛市医疗卫生重点学科和科研项目(20240358) （20240358）
