新发传染病电子杂志2025，Vol.10Issue(5)：30-35,6.DOI:10.19871/j.cnki.xfcrbzz.2025.05.006
CD4+T淋巴细胞计数与HIV感染者胆囊切除术后肺部并发症的相关性研究
Research on the relationship between CD4+T cell count and postoperative pulmonary complications in hiv-positive patients after cholecystectomy
摘要
Abstract
Objective To analyze the correlation between CD4+T lymphocyte count and postoperative pulmonary complications(including bacterial pneumonia,fungal pneumonia,pleuritis,pleural effusion,respiratory failure and other serious adverse events in the lungs)in patients with HIV infection who underwent cholecystectomy.The aim is to provide a reference for reducing postoperative pulmonary complications and optimizing perioperative management in HIV-infected patients.Method A retrospective analysis was conducted on the clinical data of 122 HIV-infected patients who underwent cholecystectomy at the Chengdu Public Health Clinical Medical Center between June 2017 and November 2024.Logistic regression analysis was used to evaluate the correlation between CD4+T cell count and postoperative pulmonary complications.Result Among the 122 HIV-infected patients,53(43.44%)were female and 69(56.56%)were male,with an average age of(50.24±11.97)years.The median CD4+T cell count was 366(246,481)cells/µl,and the incidence of postoperative pulmonary complications was 16.39%.Statistically significant association was observed between CD4+T cell count and postoperative pulmonary complications(OR=0.996,95%CI:0.993-0.999,P=0.021),further stratified analysis revealed significant findings.Using HIV-infected patients with CD4+T cell counts＜200 cells/µl as the reference group,those with CD4+T cell counts≥500 cells/µl demonstrated a negative correlation with postoperative pulmonary complications(OR=0.154,95%CI:0.028-0.843,P=0.031).This negative association persisted after adjusting for confounding factors(OR=0.169,95%CI:0.029-0.997,P＜0.050).Conclusion The risk of pulmonary complications after cholecystectomy in HIV-infected patients was lower when the CD4+T lymphocyte count was≥500 cells/µl.Effective antiviral therapy should be administered to HIV-infected patients to maintain adequate CD4+T lymphocyte count and and thereby reduce the risk of postoperative pulmonary complications.关键词
CD4+T淋巴细胞/HIV感染/胆囊切除术/术后肺部并发症/相关性研究Key words
CD4+T lymphocytes/HIV infection/Cholecystectomy/Postoperative pulmonary complications/Correlation study分类
医药卫生引用本文复制引用
冯仕锋,成兴真,赵勇,陈廷玉,刘东旭,魏国..CD4+T淋巴细胞计数与HIV感染者胆囊切除术后肺部并发症的相关性研究[J].新发传染病电子杂志,2025,10(5):30-35,6.基金项目
1.成都市临床重点专科项目(2025年C50-4-5) （2025年C50-4-5）
2.成都市高新区医学会课题(202004) （202004）
