新发传染病电子杂志2025，Vol.10Issue(5)：64-68,5.DOI:10.19871/j.cnki.xfcrbzz.2025.05.012
深圳市1例本地钩端螺旋体病例流行病学调查
Epidemiological investigation of a local case of Leptospira in Shenzhen
摘要
Abstract
Objective To conduct a field epidemiological investigation and analysis on a local case of leptospirosis in Shenzhen,providing a reference for the prevention and control of leptospirosis in urban areas.Method An epidemiological investigation and laboratory testing were conducted on a leptospirosis case reported in Nanshan District,Shenzhen on November 13,2024,along with rodent density monitoring at potential exposure risk sites of the patient.Real-time PCR was used to detect Leptospira nucleic acid in the blood and urine samples of the case,as well as in the blood,liver,spleen,kidney tissue,and urine samples of the captured rodents,and in stream water samples.Result The early symptoms of the patient were not obvious.Six days after the onset of the disease,the patient was diagnosed as a suspected leptospirosis case based on Hirsch reaction,and then he was diagnosed as leptospirosis typhi by metagenomic next-generation sequencing and nucleic acid detection.According to the epidemiological investigation,the patient had gone to W scenic spot on foot and traced the creek three times one month before the onset of the disease,during which he was pierced by branches,and the wounds were soaked in creek water.The epidemiological investigation team set up 203 traps along both banks of the stream in the W scenic area and captured 19 rats.The positive rate of leptospira was 36.84%.No other infected persons were identified.Conclusion This patient with leptospirosis has sufficient evidence of local infection.The infection site was determined to be the W scenic area.The mode of infection is through contact with water contaminated by urine of rodents through wounds.关键词
钩端螺旋体病/赫氏反应/城市防控/流行病学调查Key words
Leptospirosis/Hirsch reaction/Urban preventionand control/Anepidemiological survey分类
医药卫生引用本文复制引用
曹丽明,万佳,孔东锋,刘威,陈戊申,旷翠萍,黄燕飞,江仕清,陈霖祥,古伟志..深圳市1例本地钩端螺旋体病例流行病学调查[J].新发传染病电子杂志,2025,10(5):64-68,5.基金项目
1.国家科技基础资源调查专项子课题委托合作项目(2022FY100904) （2022FY100904）
2.深圳市医学研究专项资金(B2404002) （B2404002）
3.深圳市医学重点学科(公共卫生重点专科)-传染病防控(SZXK064) （公共卫生重点专科）
