医学信息2025，Vol.38Issue(21)：19-24,32,7.DOI:10.3969/j.issn.1006-1959.2025.21.004
扶正化瘀胶囊/片联合一线核苷(酸)类似物治疗慢性乙肝肝纤维化的Meta分析
Meta-analysis of Fuzheng Huayu Capsule/Tablet Combined with First-line Nucleos(t)ide Analoguesin Treatment of Chronic Hepatitis B Liver Fibrosis
摘要
Abstract
Objective To systematically evaluate the efficacy and safety of Fuzheng Huayu capsule/tablet combined with first-line nucleos(t)ide analogues in the treatment of chronic hepatitis B liver fibrosis.Methods The randomized controlled trials of Fuzheng Huayu capsule/tablet combined with first-line nucleos(t)ide analogues in the treatment of chronic hepatitis B liver fibrosis in PubMed,Cochrane Library,Embase,Wanfang Database,China National Knowledge Infrastructure,VIP Database and China Biomedical Literature Database were searched by computer.The search time range was from the establishment of the database to May 2024,and Meta-analysis was performed on the literature that met the criteria.Results A total of 11 articles were finally included,involving a total of 1023 patients.The results of Meta-analysis showed that in the treatment of chronic hepatitis B liver fibrosis,Fuzheng Huayu capsule/tablet combined with first-line nucleos(t)ide analogues could improve the reversal rate of liver fibrosis[OR=2.69,95%CI(1.10,6.60),P=0.03],reduce serum liver fibrosis indexes:HA[MD=-41.43,95%CI(-57.71,-25.15),P<0.000 01],LN[MD=-27.57,95%CI(-37.75,-17.39),P<0.00001],PCⅢ[MD=-36.78,95%CI(-49.82,-23.74),P<0.000 01],IV-C[MD=-21.09,95%CI(-27.11,-15.07),P<0.000 01];meanwhile,it could reduce the liver hardness value[MD=-3.63,95%CI(-5.48,-1.78),P=0.0001],improve liver function indexes:ALT[MD=-19.37,95%CI(-25.95,-12.79),P<0.000 01],AST[MD=-12.80,95%CI(-16.74,-8.86),P<0.000 01],and no obvious adverse reactions were found.Conclusion The clinical efficacy of Fuzheng Huayu capsule/tablet combined with first-line nucleos(t)ide analogues in the treatment of chronic hepatitis B liver fibrosis is significantly better than that of first-linenucleos(t)ide analogues alone,as demonstrated by liver histopathology,imaging examinationand serological indicators.But rigorous design and quality RCTs are needed to confirm this conclusion.关键词
扶正化瘀胶囊/扶正化瘀片/核苷(酸)类似物/慢性乙型肝炎/肝纤维化/肝硬化Key words
Fuzheng Huayu capsule/Fuzheng Huayu tablet/Nucleos(t)ide analogues/Chronic hepatitis B/Liver fibrosis/Cirrhosis分类
医药卫生引用本文复制引用
梁志达,龚先琼..扶正化瘀胶囊/片联合一线核苷(酸)类似物治疗慢性乙肝肝纤维化的Meta分析[J].医学信息,2025,38(21):19-24,32,7.基金项目
1.厦门市科技计划项目(编号:3502Z20224020) （编号:3502Z20224020）
2.厦门市扶持中医药发展专项项目(编号:XWZY-2023-0610) （编号:XWZY-2023-0610）
