中国癌症杂志2025，Vol.35Issue(10)：959-967,9.DOI:10.19401/j.cnki.1007-3639.2025.10.009
微波消融与手术切除在潜在可切除的结直肠癌肝转移中的临床效果Meta分析
Microwave ablation versus hepatic resection in potentially resectable colorectal liver metastasis:a systematic review and meta-analysis
摘要
Abstract
Colorectal cancer is the third leading cause of cancer-related mortality worldwide.Hepatic resection is the standard treatment for colorectal cancer liver metastasis.Microwave ablation(MWA),as a minimally invasive therapeutic approach,offers an alternative treatment option for these patients.But the clinical efficacy of hepatic resection and MWA in treating colorectal cancer liver metastasis patients is still inconclusive.Literatures were retrieved on comparative studies about the treatment of colorectal cancer liver metastasis with hepatic resection and MWA from multiple databases,including sinoMed,PubMed,Web of Science,EMBASE,CNKI,Wanfang,etc.The cutoffdate of retrieval was September 2024.Finally,a total of 13 studies comprising 2 057 patients,were included in this study.The papers were assessed using the Newcastle-Ottawa Scale and Jadad Scale.All included studies were of high quality.Data extraction focused on postoperative complications,length of hospital stay,surgical duration,hospitalization costs,and patient survival outcomes,including overall survival(OS)and disease-free survival(DFS).A meta-analysis was performed using Review Manager 5.4 software.There were no significant differences in OS(HR=1.03,95%CI:0.85-1.25,P=0.77)and DFS(HR=1.27,95%CI:0.94-1.71,P=0.13)between the MWA group and the hepatic resection group.In the subgroup analysis of patients with≤5 liver metastases and size of metastases≤3 cm,there were no statistically significant differences in OS and DFS between the MWA group and the hepatic resection group.The MWA group exhibited shorter hospital stay,reduced hospitalization costs,decreased surgical duration,less intraoperative blood loss,and lower incidence of complications compared to the hepatic resection group(P＜0.05).Therefore,for patients with colorectal liver metastases characterized by a number of liver metastases≤5 and size of metastases≤3 cm,MWA serves as an effective alternative to hepatic resection,with a lower morbidity associated with treatment.Further validation of these findings is warranted through additional randomized controlled trials and cohort studies.The registration number of this Meta-analysis on the PROSPERO platform is CRD42024610278.关键词
结直肠癌肝转移/肝切除术/微波消融/患者生存/术后并发症/Meta分析Key words
Colorectal cancer liver metastasis/Hepatic resection/Microwave ablation/Patient survival/Postoperative complications/Meta-analysis分类
医药卫生引用本文复制引用
孟泽松,李保坤,曹龙飞,张建锋,王贵英..微波消融与手术切除在潜在可切除的结直肠癌肝转移中的临床效果Meta分析[J].中国癌症杂志,2025,35(10):959-967,9.基金项目
国家自然科学基金(82272909). National Natural Science Foundation of China(82272909). （82272909）
