中国癌症杂志2025，Vol.35Issue(10)：968-986,19.DOI:10.19401/j.cnki.1007-3639.2025.10.010
血液肿瘤合并实体肿瘤诊疗专家共识(2025年版)
Expert consensus on diagnosis and treatment of hematologic malignancies with solid tumors(2025 version)
摘要
Abstract
Hematologic malignancies with solid tumors(HM-ST),a special subtype of multiple primary malignancies(MPMs),are increasingly encountered in clinical practice,posing significant diagnostic and therapeutic challenges.The two types of tumors exhibit vast differences in biological behavior,treatment strategies,and prognosis.Treatment decisions require comprehensive consideration of prioritization,synchronous/metachronous approaches,and toxicity management.Due to the scarcity of high-quality research data,clinical practice often relies on limited experience.This consensus aimed to integrate the latest international advancements with Chinese clinical practice experience to delineate the definition,classification,epidemiology,pathogenesis[e.g.,clonal hematopoiesis of indeterminate potential(CHIP),RNA splicing abnormalities],diagnostic workflow(emphasizing pathology,molecular diagnosis,and advanced imaging techniques such as PET/CT with targeted probes),treatment principles[highlighting multidisciplinary team(MDT)collaboration,treatment prioritization,toxicity management,refined radiotherapy,and the strategy of"treating different diseases with the same method"],and follow-up management for HM-ST.This consensus specifically puts forward a series of recommendations regarding diagnosis,assessment,treatment,and follow-up,intending to provide clinicians with standardized and practical guidance,optimize individualized management for HM-ST patients,and ultimately improve their prognosis and quality of life.This consensus has been registered on the Practice guideline REgistration for transPAREncy(PREPARE)platform(registration number:PREPARE-2025CN1599).关键词
血液肿瘤/实体肿瘤/多原发肿瘤/治疗/专家共识Key words
Hematologic malignancies/Solid tumors/Multiple primary malignancies/Treatment/Expert consensus分类
医药卫生引用本文复制引用
中国抗癌协会多原发和不明原发肿瘤专业委员会,上海市抗癌协会多原发和不明原发肿瘤专业委员会,中华医学会血液学分会淋巴细胞疾病学组,中华医学会血液学分会罕见病学组,罗志国,赵维莅,李荣..血液肿瘤合并实体肿瘤诊疗专家共识(2025年版)[J].中国癌症杂志,2025,35(10):968-986,19.基金项目
国家自然科学基金(82573699). National Natural Science Foundation of China(82573699). （82573699）
